Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK11 | Q15759 | 2/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.43 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.43 |
| ▸ | RAF1 | P04049 | 1/20 | 0.43 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.43 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.43 |
| ▸ | PRCP | P42785 | 1/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.40 |
| ▸ | TNKS | O95271 | 5/20 | 0.38 |
| ▸ | TNKS2 | Q9H2K2 | 5/20 | 0.38 |
| ▸ | PARP1 | P09874 | 5/20 | 0.38 |
| ▸ | PLAT | P00750 | 3/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17073562 | 0.88 | MAPK11 (0.51) | MAPK11MAPK14MAPK13RAF1MAPK9 | |
| Trifluoroacetic Acid SCHEMBL3899109 | 0.85 | PARP1 (0.33) | TNKSTNKS2PARP1PLATPARP2 | |
| Trifluoroacetic Acid SCHEMBL29562329 | 0.83 | HPGDS (0.44) | PARP1 | |
| Trifluoroacetic Acid SCHEMBL1501844 | 0.80 | PLAT (0.46) | MKNK1MKNK2PLATKCNH2 | |
| SCHEMBL19428036 | 0.80 | PTGS1 (0.49) | MAPK11MAPK14MAPK13RAF1MAPK9 | |
| SCHEMBL2755237 | 0.79 | HTR2C (0.54) | MAPK11MAPK14MAPK13RAF1MAPK9 | |
| Hydrochloric Acid SCHEMBL237629 | 0.78 | HTR2C (0.55) | MAPK11MAPK14MAPK13RAF1MAPK9 | |
| Trifluoroacetic Acid SCHEMBL2277078 | 0.78 | SCN9A (0.39) | MAPK11MAPK14MAPK13RAF1MAPK9 | |
| SCHEMBL2755234 | 0.77 | CHEK2 (0.46) | PARP1PARP2 | |
| SCHEMBL3941345 | 0.77 | HPGDS (0.50) | PLATKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9771369-B2 | Compounds and methods for kinase modulation, and indications therefor | PLEXXIKON INC. (US) | 2017-09-26 | — | — | US | disclosed |
| US-20150284397-A1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | PLEXXIKON INC. | 2015-10-08 | — | — | US | disclosed |
| WO-2015134536-A1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | PLEXXIKON INC. (US) | 2015-09-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150284397-A1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | KIT, PRKCH, PRKACA | MAPK11 136/4885MAPK14 169/4885MAPK13 76/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.