Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 4/20 | 0.54 |
| ▸ | PLAT | P00750 | 4/20 | 0.44 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.43 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.40 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.40 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.40 |
| ▸ | RAF1 | P04049 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | P2RY14 | Q15391 | 7/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL237629 | 0.99 | HTR2C (0.55) | HTR2CPLATPRMT5MAPK13MAPK9 | |
| SCHEMBL2755235 | 0.84 | MEN1 (0.56) | HTR2CPLATMAPK13MAPK9MAPK12 | |
| SCHEMBL17073562 | 0.84 | MAPK11 (0.51) | PLATMAPK13MAPK9MAPK12MAPK11 | |
| Hydrochloric Acid SCHEMBL238482 | 0.83 | HTR2C (0.56) | HTR2CPLATMAPK13MAPK9MAPK12 | |
| SCHEMBL2755242 | 0.82 | MAPK11 (0.49) | PLATMAPK13MAPK9MAPK12MAPK11 | |
| SCHEMBL2755245 | 0.81 | PLAT (0.42) | HTR2CPLATPRMT5MAPK13MAPK9 | |
| SCHEMBL3941345 | 0.80 | HPGDS (0.50) | HTR2CPLATPOLBSIGMAR1 | |
| Hydrochloric Acid SCHEMBL236033 | 0.80 | PLAT (0.41) | HTR2CPLATPRMT5MAPK13MAPK9 | |
| Hydrochloric Acid SCHEMBL31583814 | 0.79 | HTR3A (0.42) | HTR2CPLATMAPK13MAPK9MAPK12 | |
| Trifluoroacetic Acid SCHEMBL17065161 | 0.79 | MAPK11 (0.43) | PLATMAPK13MAPK9MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120004240-A1 | INHIBITORS OF AKT ACTIVITY | MERCK SHARP & DOHME LLC | 2012-01-05 | — | — | US | disclosed |
| US-20120004240-A1 | INHIBITORS OF AKT ACTIVITY | MERCK SHARP & DOHME LLC | 2012-01-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120004240-A1 | INHIBITORS OF AKT ACTIVITY | PIK3CD, PIK3CA, PIK3R5 | HTR2C 4004/4885PLAT 1906/4885PRMT5 796/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.