Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 10/20 | 0.55 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.51 |
| ▸ | CDK1 | P06493 | 1/20 | 0.51 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.51 |
| ▸ | GSK3A | P49840 | 1/20 | 0.51 |
| ▸ | GSK3B | P49841 | 1/20 | 0.51 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.51 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.51 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.51 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | ULK1 | O75385 | 3/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28323721 | 0.84 | CCNB2 (0.51) | CCNB2CDK1CCNB1CCNB3RIPK1 | |
| SCHEMBL180217 | 0.83 | CCNB2 (0.50) | KITCCNB2CDK1CCNB1GSK3A | |
| SCHEMBL31308681 | 0.83 | ULK1 (0.39) | KITCCNB2CDK1CCNB1GSK3A | |
| SCHEMBL18952058 | 0.80 | CCNB2 (0.54) | KITCCNB2CDK1CCNB1GSK3A | |
| SCHEMBL15824567 | 0.79 | KIT (0.52) | KITCCNB2CDK1CCNB1GSK3A | |
| SCHEMBL7230038 | 0.79 | RIPK1 (0.52) | RIPK1EGFR | |
| Hydrochloric Acid SCHEMBL15824944 | 0.78 | KIT (0.51) | KITCCNB2CDK1CCNB1GSK3A | |
| SCHEMBL31308645 | 0.78 | KIT (0.47) | KITCCNB2CDK1CCNB1CDK5 | |
| SCHEMBL16977987 | 0.76 | KIT (0.55) | KITCCNB2CDK1CCNB1GSK3A | |
| SCHEMBL31447389 | 0.76 | CCNB2 (0.50) | KITCCNB2CDK1CCNB1GSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015134536-A1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | PLEXXIKON INC. (US) | 2015-09-11 | — | — | WO | disclosed |