SCHEMBL1706586

SCHEMBL1706586

NSc1nc2c(N3CCOCC3)cccc2s1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 6/20 0.48
ALDH1A1 P00352 4/20 0.43
HSD17B10 Q99714 3/20 0.43
PKM P14618 2/20 0.43
ALOX15 P16050 2/20 0.43
KDM4E B2RXH2 2/20 0.43
HPGD P15428 2/20 0.43
MAPT P10636 5/20 0.43
NPC1 O15118 5/20 0.43
RAB9A P51151 5/20 0.43
POLB P06746 2/20 0.43
GAA P10253 2/20 0.43
MEN1 O00255 2/20 0.43
KMT2A Q03164 2/20 0.43
L3MBTL1 Q9Y468 2/20 0.43
THRB P10828 1/20 0.43
RECQL P46063 1/20 0.43
BLM P54132 1/20 0.43
FGFR1 P11362 1/20 0.38
NCF1 P14598 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2192308 0.89 SMN1; SMN2 (0.50) SMN1; SMN2ALDH1A1HSD17B10PKMALOX15
SCHEMBL28543507 0.86 SMN1; SMN2 (0.48) SMN1; SMN2ALDH1A1HSD17B10PKMALOX15
SCHEMBL8826783 0.86 SMN1; SMN2 (0.48) SMN1; SMN2ALDH1A1HSD17B10PKMALOX15
SCHEMBL28543509 0.85 SMN1; SMN2 (0.47) SMN1; SMN2ALDH1A1HSD17B10PKMALOX15
SCHEMBL19207393 0.82 SMN1; SMN2 (0.51) SMN1; SMN2ALDH1A1ALOX15MAPTNPC1
SCHEMBL8089188 0.82 MAPT (0.41) SMN1; SMN2ALDH1A1HSD17B10PKMALOX15
SCHEMBL10757407 0.80 SMN1; SMN2 (0.43) SMN1; SMN2ALDH1A1HSD17B10PKMALOX15
SCHEMBL9305319 0.80 SMN1; SMN2 (0.52) SMN1; SMN2ALDH1A1ALOX15HPGDMAPT
SCHEMBL8088211 0.79 ALDH1A1 (0.53) SMN1; SMN2ALDH1A1HSD17B10PKMALOX15
SCHEMBL9734113 0.79 SMN1; SMN2 (0.51) SMN1; SMN2ALDH1A1HSD17B10PKMALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8562927-B2 Absorbent solution containing a breakdown inhibitor derived from thiazole or from oxazole and absorption process for acid compounds contained in a gaseous effluent IFP (FR) 2013-10-22 US claimed
US-20120308452-A1 ABSORBENT SOLUTION CONTAINING A BREAKDOWN INHIBITOR DERIVED FROM THIAZOLE OR FROM OXAZOLE AND ABSORPTION PROCESS FOR ACID COMPOUNDS CONTAINED IN A GASEOUS EFFLUENT IFP (FR) 2012-12-06 US claimed
EP-2506951-A1 ABSORBENT SOLUTION CONTAINING A BREAKDOWN INHIBITOR DERIVED FROM THIAZOLE OR FROM OXAZOLE AND ABSORPTION PROCESS FOR ACID COMPOUNDS CONTAINED IN A GASEOUS EFFLUENT IFP Energies nouvelles (FR) 2012-10-10 EP claimed
WO-2011064469-A1 ABSORBENT SOLUTION CONTAINING A BREAKDOWN INHIBITOR DERIVED FROM THIAZOLE OR FROM OXAZOLE AND ABSORPTION PROCESS FOR ACID COMPOUNDS CONTAINED IN A GASEOUS EFFLUENT IFP Energies Nouvelles (FR) 2011-06-03 WO claimed
US-5302315-A Zinc salts of carboxylic acids SCHILL & SEILACHER (GMBH & CO.) (DE) 1994-04-12 US claimed
CN-113423585-A Tire with outer sidewall 米其林集团总公司 2021-09-21 CN disclosed
CN-113165427-A Tread for aircraft tire 米其林集团总公司 2021-07-23 CN disclosed
WO-2021112167-A1 POLYMER COMPOSITION MANUFACTURING METHOD JSR株式会社 2021-06-10 WO disclosed
US-9441099-B2 Olefinic Thermoplastic Elastomer composition and process for producing the same Rubber Recycling Technologies Ltd. (IL) 2016-09-13 US disclosed
US-8562927-B2 Absorbent solution containing a breakdown inhibitor derived from thiazole or from oxazole and absorption process for acid compounds contained in a gaseous effluent IFP (FR) 2013-10-22 US disclosed
EP-2646507-A1 OLEFINIC THERMOPLASTIC ELASTOMER COMPOSITION AND PROCESS FOR PRODUCING THE SAME RUBBER RECYCLING TECHNOLOGIES LTD. (IL) 2013-10-09 EP disclosed
US-20130253123-A1 OLEFINIC THERMOPLASTIC ELASTOMER COMPOSITION AND PROCESS FOR PRODUCING THE SAME Rubber Recycling Technologies Ltd. 2013-09-26 US disclosed
EP-0442143-B1 Method of preparing fillers which are modified by organosilicon compounds, the products thus obtained and their use DEGUSSA (DE) 1993-12-15 EP disclosed
US-5254709-A Catalytic reaction of phosphorus trihalide with a phenolic compound UNIROYAL CHEMICAL COMPANY, INC. (US) 1993-10-19 US disclosed
EP-0504320-A1 METHOD FOR PREPARING STERICALLY HINDERED ARYL PHOSPHITES. UNIROYAL CHEM CO INC (US) 1992-09-23 EP disclosed
US-5104941-A With a sulfur-vulcanizable elastomer; improved wet skid resistance HUELS AKTIENGESELLSCHAFT (DE) 1992-04-14 US disclosed
WO-1991009040-A1 METHOD FOR PREPARING STERICALLY HINDERED ARYL PHOSPHITES UNIROYAL CHEMICAL COMPANY, INC. (US) 1991-06-27 WO disclosed
EP-0131776-B1 PROCESS FOR THE PREPARATION OF THIAZOLE-2-SULFENAMIDES Akzo Patente GmbH (DE) 1990-02-28 EP disclosed
US-4670556-A BY-PRODUCT INHIBITION AKZO NV (NL) 1987-06-02 US disclosed
EP-0131776-A2 Process for the preparation of thiazole-2-sulfenamides Akzo Patente GmbH (DE) 1985-01-23 EP disclosed