Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 19/20 | 0.50 |
| ▸ | CTSB | P07858 | 18/20 | 0.50 |
| ▸ | CTSK | P43235 | 18/20 | 0.50 |
| ▸ | CTSL | P07711 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL347551 | 0.85 | CTSS (0.71) | CTSSCTSBCTSKCTSL | |
| SCHEMBL8223397 | 0.82 | CTSB (0.66) | CTSSCTSBCTSKUSP2CYP3A4 | |
| SCHEMBL346102 | 0.81 | CTSS (0.74) | CTSSCTSBCTSKCTSL | |
| SCHEMBL8224558 | 0.80 | CTSB (0.73) | CTSSCTSBCTSK | |
| SCHEMBL8224236 | 0.79 | CTSS (0.76) | CTSSCTSBCTSKCYP3A4 | |
| SCHEMBL8229166 | 0.79 | CTSB (0.76) | CTSSCTSBCTSK | |
| SCHEMBL11917586 | 0.78 | CTSS (0.71) | CTSSCTSBCTSK | |
| SCHEMBL8225937 | 0.78 | CTSB (0.67) | CTSSCTSBCTSK | |
| SCHEMBL8226527 | 0.78 | CTSB (0.79) | CTSSCTSBCTSK | |
| SCHEMBL346609 | 0.78 | CTSS (0.56) | CTSSCTSBCTSKCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2520568-B1 | Spirocyclic nitriles as inhibitors of protease | SANOFI SA (FR) | 2015-09-09 | — | — | EP | disclosed |