Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT1 | P17948 | 7/20 | 0.34 |
| ▸ | KDR | P35968 | 7/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 3/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | GLA | P06280 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13141164 | 0.83 | FLT1 (0.37) | FLT1KDRCA12CA1CA2 | |
| SCHEMBL23971227 | 0.77 | FLT1 (0.35) | FLT1KDRCA12CA1CA2 | |
| SCHEMBL23971229 | 0.76 | FLT1 (0.34) | FLT1KDRCA12CA1CA2 | |
| SCHEMBL23971010 | 0.76 | FLT1 (0.34) | FLT1KDRCA12CA1CA2 | |
| SCHEMBL29069810 | 0.74 | L3MBTL1 (0.37) | FLT1KDRNPC1RAB9AGAA | |
| SCHEMBL30159053 | 0.74 | SMN1; SMN2 (0.50) | NPC1RAB9AGAAKDM4EALDH1A1 | |
| SCHEMBL31518503 | 0.72 | SMN1; SMN2 (0.44) | MAPK1NPC1GAAKDM4EALDH1A1 | |
| SCHEMBL28113504 | 0.69 | F2 (0.40) | CA12CA1CA2CA9CA14 | |
| SCHEMBL31646524 | 0.68 | DRD2 (0.46) | CA12CA1CA2CA9GAA | |
| SCHEMBL28739878 | 0.68 | ELANE (0.42) | MAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2149561-B1 | TETRAHYDROISOQUINOLIN-1-ONE DERIVATIVE OR SALT THEREOF | SELDAR PHARMA INC (US) | 2015-09-09 | — | — | EP | disclosed |