Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 16/20 | 0.54 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.49 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11598566 | 0.86 | CA1 (0.55) | CA1CA2ACHE | |
| SCHEMBL17067873 | 0.81 | FAAH (0.51) | FAAHMCHR1 | |
| SCHEMBL17067937 | 0.79 | FAAH (0.68) | FAAH | |
| SCHEMBL17067891 | 0.79 | FAAH (0.69) | FAAH | |
| SCHEMBL12472187 | 0.78 | FAAH (0.48) | FAAHMCHR1 | |
| SCHEMBL12471707 | 0.78 | FAAH (0.67) | FAAH | |
| SCHEMBL11476520 | 0.77 | CA1 (0.53) | CA1CA2ACHE | |
| SCHEMBL9367720 | 0.76 | KMT2A (0.43) | — | |
| SCHEMBL12472224 | 0.75 | FAAH (0.48) | FAAHMCHR1 | |
| SCHEMBL10197685 | 0.74 | FAAH (0.60) | FAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9504675-B2 | Alpha-ketoheterocycles and methods of making and using | THE SCRIPPS RESEARCH INSTITUTE (US) | 2016-11-29 | — | — | US | disclosed |
| US-9504675-B2 | Alpha-ketoheterocycles and methods of making and using | THE SCRIPPS RESEARCH INSTITUTE (US) | 2016-11-29 | — | — | US | disclosed |
| US-9504675-B2 | Alpha-ketoheterocycles and methods of making and using | THE SCRIPPS RESEARCH INSTITUTE (US) | 2016-11-29 | — | — | US | disclosed |
| EP-2670245-B1 | ALPHA-KETOHETEROCYCLES AND METHODS OF MAKING AND USING | SCRIPPS RESEARCH INST (US) | 2015-09-09 | — | — | EP | disclosed |
| EP-2670245-B1 | ALPHA-KETOHETEROCYCLES AND METHODS OF MAKING AND USING | SCRIPPS RESEARCH INST (US) | 2015-09-09 | — | — | EP | disclosed |
| US-20130338196-A1 | ALPHA-KETOHETEROCYCLES AND METHODS OF MAKING AND USING | THE SCRIPPS RESEARCH INSTITUTE (US) | 2013-12-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130338196-A1 | ALPHA-KETOHETEROCYCLES AND METHODS OF MAKING AND USING | FAAH, FAAH2, CNR2 | FAAH 1/4885MCHR1 1485/4885NPY5R 693/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.