Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.35 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | SLC6A9 | P48067 | 4/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.31 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.31 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.31 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15233372 | 0.87 | HRH3 (0.39) | SMN1; SMN2DPP8DPP7DPP4SLC6A9 | |
| SCHEMBL14748113 | 0.77 | NR1H3 (0.39) | SMN1; SMN2 | |
| SCHEMBL17067941 | 0.77 | NR1H3 (0.39) | SMN1; SMN2 | |
| SCHEMBL23735937 | 0.77 | JAK3 (0.39) | SMN1; SMN2KDM4E | |
| SCHEMBL14748116 | 0.74 | KDM4E (0.46) | KDM4EACHE | |
| SCHEMBL13130609 | 0.73 | TSHR (0.43) | SMN1; SMN2PDK1PDK2PDK3PDK4 | |
| SCHEMBL10196629 | 0.73 | TSHR (0.34) | PDK1PDK2PDK3PDK4 | |
| SCHEMBL3393183 | 0.73 | PDK1 (0.43) | PDK1PDK2PDK3PDK4 | |
| SCHEMBL17067975 | 0.71 | DPP8 (0.37) | DPP8DPP7DPP4ACHE | |
| SCHEMBL20008949 | 0.70 | HRH3 (0.38) | SMN1; SMN2SLC6A9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2389372-B1 | COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY | RIGEL PHARMACEUTICALS INC (US) | 2015-09-09 | — | — | EP | disclosed |