Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP8 | Q6V1X1 | 5/20 | 0.37 |
| ▸ | DPP4 | P27487 | 5/20 | 0.37 |
| ▸ | DPP7 | Q9UHL4 | 3/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | JAK1 | P23458 | 1/20 | 0.31 |
| ▸ | TYK2 | P29597 | 1/20 | 0.31 |
| ▸ | JAK3 | P52333 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10283700 | 0.85 | HRH3 (0.35) | DPP8DPP4DPP7ACHEJAK2 | |
| SCHEMBL20682285 | 0.80 | DPP4 (0.32) | DPP8DPP4DPP7JAK2JAK1 | |
| SCHEMBL10196653 | 0.73 | HSD11B1 (0.33) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL17067967 | 0.73 | LMNA (0.34) | — | |
| SCHEMBL20071281 | 0.73 | CYP2D6 (0.30) | — | |
| SCHEMBL18500425 | 0.72 | CHRM2 (0.33) | DPP8DPP4DPP7 | |
| SCHEMBL14748116 | 0.71 | KDM4E (0.46) | ACHE | |
| SCHEMBL17067968 | 0.71 | SMN1; SMN2 (0.36) | DPP8DPP4DPP7ACHE | |
| SCHEMBL23283026 | 0.70 | HRH3 (0.33) | — | |
| SCHEMBL22030752 | 0.69 | RECQL (0.44) | TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2389372-B1 | COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY | RIGEL PHARMACEUTICALS INC (US) | 2015-09-09 | — | — | EP | disclosed |