Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | TYR | P14679 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
| ▸ | FDPS | P14324 | 1/20 | 0.39 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.39 |
| ▸ | TTR | P02766 | 1/20 | 0.38 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27677687 | 1.00 | KMT2A (0.44) | KMT2AMEN1KDM4ESMN1; SMN2CA12 | |
| SCHEMBL30288849 | 0.83 | XPO1 (0.37) | KMT2ASMN1; SMN2CYP2C9CYP2C19SIRT6 | |
| SCHEMBL1707589 | 0.83 | CA12 (0.45) | KDM4ECA12CA1CA2CA7 | |
| SCHEMBL15278589 | 0.83 | XPO1 (0.37) | KMT2ASMN1; SMN2CYP2C9CYP2C19SIRT6 | |
| SCHEMBL20411828 | 0.81 | KMT2A (0.45) | KMT2AMEN1KDM4ESMN1; SMN2CA12 | |
| SCHEMBL3310811 | 0.80 | NFE2L2 (0.47) | KMT2AMEN1KDM4ESMN1; SMN2CA12 | |
| SCHEMBL3223472 | 0.79 | SIRT6 (0.46) | KDM4ESMN1; SMN2CA12CA1CA2 | |
| SCHEMBL3223457 | 0.79 | SIRT6 (0.46) | KDM4ESMN1; SMN2CA12CA1CA2 | |
| SCHEMBL3772961 | 0.75 | CA12 (0.56) | KMT2AMEN1KDM4ESMN1; SMN2CA12 | |
| SCHEMBL3772958 | 0.75 | CA12 (0.56) | KMT2AMEN1KDM4ESMN1; SMN2CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1981877-B1 | N-HYDROXYACRYLAMIDE COMPOUNDS | ASTELLAS PHARMA INC (JP) | 2012-04-18 | — | — | EP | disclosed |
| CN-101001851-B | Hydroxyamide compounds having activity as inhibitors of histone deacetylase (HDAC) | ASTELLAS PHARMA INC | 2011-04-20 | — | — | CN | disclosed |
| CN-101583599-A | N-hydroxyacrylamide compounds | ASTELLAS PHARMA INC (JP) | 2009-11-18 | — | — | CN | disclosed |
| CN-101379059-A | N-hydroxyacrylamide compounds | ASTELLAS PHARMA INC (JP) | 2009-03-04 | — | — | CN | disclosed |
| CN-101001851-A | Hydroxyamide compounds having activity as inhibitors of histone deacetylase (HDAC) | ASTELLAS PHARMA INC (JP) | 2007-07-18 | — | — | CN | disclosed |