Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLA | P06280 | 1/20 | 0.64 |
| ▸ | GSK3B | P49841 | 6/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 4/20 | 0.58 |
| ▸ | GSK3A | P49840 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 6/20 | 0.57 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.57 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.53 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17068760 | 0.88 | NPSR1 (0.60) | GSK3BMAPK1CYP1A2CYP2C19HTT | |
| SCHEMBL17068796 | 0.86 | GLA (0.72) | GLAGSK3BMAPK1CYP1A2CYP2C19 | |
| SCHEMBL17068758 | 0.84 | HTT (0.56) | GLAMAPK1HTTNPC1RAB9A | |
| SCHEMBL17068761 | 0.84 | SMN1; SMN2 (0.64) | GLAMAPK1HTTALDH1A1NPC1 | |
| SCHEMBL17068762 | 0.84 | HTT (0.68) | MAPK1CYP1A2CYP2C19HTTALDH1A1 | |
| SCHEMBL17068755 | 0.81 | NPC1 (0.65) | GSK3BMAPK1HTTGSK3AALDH1A1 | |
| SCHEMBL5024100 | 0.78 | GSK3B (1.00) | GSK3BMAPK1CYP1A2CYP2C19HTT | |
| SCHEMBL17068759 | 0.78 | MAPT (0.57) | GSK3BCYP1A2CYP2C19ALDH1A1NPC1 | |
| SCHEMBL17068753 | 0.78 | MAPT (0.78) | CYP1A2CYP2C19ALDH1A1NPC1RAB9A | |
| SCHEMBL16157159 | 0.75 | CYP1A2 (0.66) | GLAGSK3BMAPK1CYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150250769-A1 | METHODS AND COMPOSITIONS FOR INHIBITING RHO/MRTF-MEDIATED DISEASES AND CONDITIONS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2015-09-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150250769-A1 | METHODS AND COMPOSITIONS FOR INHIBITING RHO/MRTF-MEDIATED DISEASES AND CONDITIONS | RHOA, ARHGEF1, ARHGEF2 | GLA 1957/4885GSK3B 759/4885MAPK1 1742/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.