Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17063572 | 0.91 | TP53 (0.65) | SMN1; SMN2TP53TSHRHSD17B10ALDH1A1 | |
| SCHEMBL17078196 | 0.86 | TP53 (0.59) | SMN1; SMN2TP53TSHRHSD17B10ALDH1A1 | |
| SCHEMBL17078198 | 0.84 | TP53 (0.47) | SMN1; SMN2TP53TSHRHSD17B10ALDH1A1 | |
| SCHEMBL17068771 | 0.83 | SMN1; SMN2 (0.60) | SMN1; SMN2TP53TSHRHSD17B10ALDH1A1 | |
| SCHEMBL17068770 | 0.81 | SMN1; SMN2 (0.60) | SMN1; SMN2TP53TSHRHSD17B10ALDH1A1 | |
| SCHEMBL17068785 | 0.79 | SMN1; SMN2 (0.64) | SMN1; SMN2TP53TSHRHSD17B10ALDH1A1 | |
| SCHEMBL17068782 | 0.78 | SMN1; SMN2 (0.63) | SMN1; SMN2TP53TSHRHSD17B10ALDH1A1 | |
| SCHEMBL17068784 | 0.77 | MAPT (0.53) | SMN1; SMN2TP53TSHRALDH1A1LMNA | |
| SCHEMBL17068781 | 0.76 | TP53 (0.51) | SMN1; SMN2TP53TSHRHSD17B10ALDH1A1 | |
| SCHEMBL17063588 | 0.74 | SMN1; SMN2 (0.73) | SMN1; SMN2TP53TSHRHSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150250769-A1 | METHODS AND COMPOSITIONS FOR INHIBITING RHO/MRTF-MEDIATED DISEASES AND CONDITIONS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2015-09-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150250769-A1 | METHODS AND COMPOSITIONS FOR INHIBITING RHO/MRTF-MEDIATED DISEASES AND CONDITIONS | RHOA, ARHGEF1, ARHGEF2 | SMN1; SMN2 3070/4885TP53 1126/4885TSHR 3043/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.