Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 9/20 | 0.63 |
| ▸ | NPC1 | O15118 | 8/20 | 0.63 |
| ▸ | RAB9A | P51151 | 8/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.63 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.63 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.63 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.63 |
| ▸ | TP53 | P04637 | 4/20 | 0.61 |
| ▸ | HPGD | P15428 | 6/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.50 |
| ▸ | TSHR | P16473 | 3/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | EGFR | P00533 | 2/20 | 0.47 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17068772 | 0.89 | SMN1; SMN2 (0.58) | SMN1; SMN2NPC1RAB9AL3MBTL1CYP1A2 | |
| SCHEMBL17063608 | 0.79 | SMN1; SMN2 (0.86) | SMN1; SMN2NPC1RAB9AL3MBTL1CYP1A2 | |
| SCHEMBL28284583 | 0.79 | SMN1; SMN2 (0.62) | SMN1; SMN2NPC1RAB9AL3MBTL1CYP1A2 | |
| SCHEMBL17063593 | 0.78 | SMN1; SMN2 (0.84) | SMN1; SMN2NPC1RAB9AL3MBTL1CYP1A2 | |
| SCHEMBL2640764 | 0.76 | SMN1; SMN2 (0.65) | SMN1; SMN2NPC1RAB9AL3MBTL1CYP1A2 | |
| SCHEMBL17063579 | 0.76 | SMN1; SMN2 (1.00) | SMN1; SMN2NPC1RAB9AL3MBTL1CYP1A2 | |
| SCHEMBL17063604 | 0.75 | SMN1; SMN2 (0.64) | SMN1; SMN2NPC1RAB9AL3MBTL1CYP1A2 | |
| SCHEMBL28767567 | 0.75 | MAPT (0.50) | SMN1; SMN2NPC1RAB9AL3MBTL1CYP1A2 | |
| SCHEMBL11475700 | 0.73 | NPC1 (0.77) | SMN1; SMN2NPC1RAB9AL3MBTL1CYP1A2 | |
| SCHEMBL17068783 | 0.73 | SMN1; SMN2 (0.77) | SMN1; SMN2NPC1RAB9AL3MBTL1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150250769-A1 | METHODS AND COMPOSITIONS FOR INHIBITING RHO/MRTF-MEDIATED DISEASES AND CONDITIONS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2015-09-10 | — | — | US | disclosed |
| US-20150250769-A1 | METHODS AND COMPOSITIONS FOR INHIBITING RHO/MRTF-MEDIATED DISEASES AND CONDITIONS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2015-09-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150250769-A1 | METHODS AND COMPOSITIONS FOR INHIBITING RHO/MRTF-MEDIATED DISEASES AND CONDITIONS | RHOA, ARHGEF1, ARHGEF2 | SMN1; SMN2 3070/4885NPC1 954/4885RAB9A 309/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.