Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 1/20 | 0.56 |
| ▸ | NOS2 | P35228 | 5/20 | 0.40 |
| ▸ | NOS1 | P29475 | 4/20 | 0.40 |
| ▸ | TSHR | P16473 | 4/20 | 0.40 |
| ▸ | NOS3 | P29474 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.37 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.37 |
| ▸ | ARG2 | P78540 | 4/20 | 0.37 |
| ▸ | ARG1 | P05089 | 3/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL28160064 | 1.00 | GSR (0.56) | GSRNOS2NOS1TSHRNOS3 | |
| SCHEMBL10187385 | 0.84 | TSHR (0.51) | GSRNOS2NOS1TSHRNOS3 | |
| SCHEMBL28160062 | 0.82 | THRB (0.45) | GSRTSHRTHRB | |
| SCHEMBL28535443 | 0.82 | THRB (0.45) | GSRTSHRTHRB | |
| Lysine SCHEMBL16969535 | 0.80 | GSR (0.74) | GSRNOS2NOS1TSHRNOS3 | |
| SCHEMBL10187387 | 0.80 | THRB (0.47) | GSRNOS2NOS1TSHRNOS3 | |
| Lysine SCHEMBL28536918 | 0.80 | GSR (0.74) | GSRNOS2NOS1TSHRNOS3 | |
| Lysine SCHEMBL16969536 | 0.80 | GSR (0.74) | GSRNOS2NOS1TSHRNOS3 | |
| Lysine SCHEMBL28689762 | 0.79 | GSR (0.67) | GSRNOS2NOS1TSHRNOS3 | |
| Lysine SCHEMBL28535445 | 0.79 | GSR (0.57) | GSRNOS2NOS1TSHRNOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120058327-A1 | Robust Hybrid Thin Films that Incorporate Lamellar Phospholipid Bilayer Assemblies and Transmembrane Proteins | STC.UNM (US) | 2012-03-08 | — | — | US | claimed |