SCHEMBL10187385

SCHEMBL10187385

C=C(C)C(=O)OCCCC(N)C(=O)O

nearest known ligand 0.51

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
TSHR P16473 4/20 0.51
NOS2 P35228 5/20 0.45
NOS1 P29475 4/20 0.45
NOS3 P29474 3/20 0.45
MEN1 O00255 1/20 0.45
CYP2C19 P33261 1/20 0.45
KMT2A Q03164 1/20 0.45
THRB P10828 1/20 0.44
GSR P00390 1/20 0.44
CYP1A2 P05177 1/20 0.44
CYP3A4 P08684 1/20 0.44
POLB P06746 1/20 0.43
APEX1 P27695 1/20 0.43
HTT P42858 1/20 0.43
TDP1 Q9NUW8 1/20 0.43
BLM P54132 1/20 0.42
DDAH1 O94760 2/20 0.41
ARG1 P05089 3/20 0.41
ARG2 P78540 3/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10187387 0.89 THRB (0.47) TSHRNOS2NOS1NOS3MEN1
SCHEMBL18472741 0.86 NOS2 (0.45) TSHRNOS2NOS1NOS3MEN1
SCHEMBL12520127 0.86 NOS2 (0.47) TSHRNOS2NOS1NOS3MEN1
Lysine SCHEMBL170703 0.84 GSR (0.56) TSHRNOS2NOS1NOS3MEN1
Lysine SCHEMBL28160064 0.84 GSR (0.56) TSHRNOS2NOS1NOS3MEN1
SCHEMBL19987937 0.84 NOS2 (0.40) TSHRNOS2NOS1NOS3MEN1
SCHEMBL689290 0.82 THRB (0.45) TSHRNOS2NOS1NOS3MEN1
SCHEMBL15305190 0.82 NOS2 (0.50) TSHRNOS2NOS1NOS3MEN1
SCHEMBL1170461 0.81 NOS2 (0.40) TSHRNOS2NOS1NOS3MEN1
SCHEMBL826663 0.81 GSR (0.50) TSHRNOS2NOS1NOS3MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 49 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12037405-B2 Anti-CD70 antibody drug conjugates AMBRX, INC. 2024-07-16 US disclosed
US-11786578-B2 Modified relaxin polypeptides and their uses AMBRX, INC. (US) 2023-10-17 US disclosed
US-20230302150-A1 ANTIBODY-TLR AGONIST CONJUGATES, METHODS AND USES THEREOF AMBRX, INC. (US) 2023-09-28 US disclosed
US-20230295320-A1 Anti-CD70 Antibody Drug Conjugates AMBRX, INC. (US) 2023-09-21 US disclosed
US-20230226152-A1 INTERLEUKIN-2 POLYPEPTIDE CONJUGATES AND METHODS OF USE THEREOF AMBRX, INC. 2023-07-20 US disclosed
US-20170226178-A1 THERAPEUTIC USES OF MODIFIED RELAXIN POLYPEPTIDES AMBRX, INC. 2017-08-10 US disclosed
US-9637441-B2 Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides AMBRX, INC. (US) 2017-05-02 US disclosed
US-9567386-B2 Therapeutic uses of modified relaxin polypeptides AMBRX, INC. (US) 2017-02-14 US disclosed
US-9517273-B2 Methods of treatment using modified FGF-21 polypeptides comprising non-naturally occurring amino acids AMBRX, INC. (US) 2016-12-13 US disclosed
US-9452222-B2 Nucleic acids encoding modified relaxin polypeptides AMBRX, INC. (US) 2016-09-27 US disclosed
US-20120046229-A1 MODIFIED RELAXIN POLYPEPTIDES AND THEIR USES AMBRX, INC. (US) 2012-02-23 US disclosed
US-20120041180-A1 Modified Human Plasma Polypeptide or Fc Scaffolds and Their Uses AMBRX, INC. (US) 2012-02-16 US disclosed
US-20110294161-A1 Modified Human Growth Hormone AMBRX, INC. (US) 2011-12-01 US disclosed
US-20110288279-A1 COMPOSITIONS CONTAINING, METHODS INVOLVING, AND USES OF NON-NATURAL AMINO ACIDS AND POLYPEPTIDES AMBRX, INC. (US) 2011-11-24 US disclosed
US-20110207914-A1 Modified Human Plasma Polypeptide or Fc Scaffolds and Their Uses AMBRX, INC. (US) 2011-08-25 US disclosed
US-20110178029-A1 Modified Human Apolipoprotein A-1 and Their Uses AMBRX, INC. (US) 2011-07-21 US disclosed
US-20110172401-A1 Modified FGF-21 Polypeptides and Their Uses AMBRX, INC. (US) 2011-07-14 US disclosed
US-20110124880-A1 COMPOSITIONS CONTAINING, METHODS INVOLVING, AND USES OF NON-NATURAL AMINO ACIDS AND POLYPEPTIDES AMBRX, INC. (US) 2011-05-26 US disclosed
US-20110118451-A1 COMPOSITIONS CONTAINING, METHODS INVOLVING, AND USES OF NON-NATURAL AMINO ACIDS AND POLYPEPTIDES AMBRX, INC. (US) 2011-05-19 US disclosed
US-20110118501-A1 COMPOSITIONS CONTAINING, METHODS INVOLVING, AND USES OF NON-NATURAL AMINO ACIDS AND POLYPEPTIDES AMBRX, INC. (US) 2011-05-19 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (15 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110178029-A1 Modified Human Apolipoprotein A-1 and Their Uses APOB, APOL1, HDLBP TSHR 2875/4885NOS2 4258/4885NOS1 3493/4885
US-20110288279-A1 COMPOSITIONS CONTAINING, METHODS INVOLVING, AND USES OF NON-NATURAL AMINO ACIDS AND POLYPEPTIDES PTMS, DAO, DNPEP TSHR 1876/4885NOS2 21/4885NOS1 40/4885
US-20230226152-A1 INTERLEUKIN-2 POLYPEPTIDE CONJUGATES AND METHODS OF USE THEREOF IL2, IL2RA, TAP2 TSHR 464/4885NOS2 1049/4885NOS1 4161/4885
US-12037405-B2 Anti-CD70 antibody drug conjugates CD74, CD63, CD47 TSHR 3236/4885NOS2 1667/4885NOS1 2210/4885
US-20110118501-A1 COMPOSITIONS CONTAINING, METHODS INVOLVING, AND USES OF NON-NATURAL AMINO ACIDS AND POLYPEPTIDES PTMS, DAO, DNPEP TSHR 1876/4885NOS2 21/4885NOS1 40/4885
US-20120041180-A1 Modified Human Plasma Polypeptide or Fc Scaffolds and Their Uses FGB, FCGR3B, FCGR2A TSHR 1412/4885NOS2 3197/4885NOS1 3630/4885
US-20120046229-A1 MODIFIED RELAXIN POLYPEPTIDES AND THEIR USES RXFP1, RXFP2, RXFP4 TSHR 43/4885NOS2 1488/4885NOS1 2469/4885
US-20110172401-A1 Modified FGF-21 Polypeptides and Their Uses FGF2, FGF1, FGF23 TSHR 602/4885NOS2 2852/4885NOS1 3622/4885
US-20110124880-A1 COMPOSITIONS CONTAINING, METHODS INVOLVING, AND USES OF NON-NATURAL AMINO ACIDS AND POLYPEPTIDES PTMS, DAO, DNPEP TSHR 1876/4885NOS2 21/4885NOS1 40/4885
US-20110118451-A1 COMPOSITIONS CONTAINING, METHODS INVOLVING, AND USES OF NON-NATURAL AMINO ACIDS AND POLYPEPTIDES PTMS, DAO, DNPEP TSHR 1876/4885NOS2 21/4885NOS1 40/4885
US-20230302150-A1 ANTIBODY-TLR AGONIST CONJUGATES, METHODS AND USES THEREOF TLR3, TLR1, TLR9 TSHR 543/4885NOS2 4241/4885NOS1 4297/4885
US-20110207914-A1 Modified Human Plasma Polypeptide or Fc Scaffolds and Their Uses FGB, FCGR3B, FCGR2A TSHR 1412/4885NOS2 3197/4885NOS1 3630/4885
US-20170226178-A1 THERAPEUTIC USES OF MODIFIED RELAXIN POLYPEPTIDES RXFP1, RXFP2, RXFP3 TSHR 387/4885NOS2 359/4885NOS1 576/4885
US-20230295320-A1 Anti-CD70 Antibody Drug Conjugates CD63, CD74, CD99 TSHR 3553/4885NOS2 2216/4885NOS1 2705/4885
US-11786578-B2 Modified relaxin polypeptides and their uses RXFP1, RXFP2, RXFP3 TSHR 422/4885NOS2 396/4885NOS1 624/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.