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Sugi Predict / Compounds / SCHEMBL1707135

SCHEMBL1707135

SCHEMBL1707135

Cc1cccc(-c2oc(C)nc2C(=O)Nc2coc(CCCCC(C)(F)F)n2)c1

nearest known ligand 0.59

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ FPR2 P25090 14/20 0.59
▸ HCRTR2 O43614 5/20 0.40
▸ HCRTR1 O43613 2/20 0.40
▸ RXRA P19793 1/20 0.36
▸ RXRB P28702 1/20 0.36
▸ RXRG P48443 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1706324 0.87 FPR2 (0.54) FPR2HCRTR2HCRTR1RXRARXRB
SCHEMBL1706783 0.79 FPR2 (0.44) FPR2HCRTR2HCRTR1RXRARXRB
SCHEMBL1166629 0.77 HCRTR2 (0.58) FPR2HCRTR2HCRTR1
SCHEMBL1704153 0.74 FPR2 (1.00) FPR2HCRTR2HCRTR1
SCHEMBL2131255 0.71 FPR2 (0.78) FPR2HCRTR2HCRTR1
SCHEMBL1168158 0.71 FPR2 (0.49) FPR2HCRTR1
SCHEMBL9900708 0.70 FPR2 (0.84) FPR2HCRTR2HCRTR1
SCHEMBL9926029 0.69 FPR2 (0.77) FPR2
SCHEMBL1166217 0.69 FPR2 (0.57) FPR2HCRTR2HCRTR1
SCHEMBL1704597 0.69 FPR2 (0.72) FPR2HCRTR2HCRTR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2440536-A1 OXAZOLE AND THIAZOLE DERIVATIVES AS ALX RECEPTOR AGONISTS Actelion Pharmaceuticals Ltd. (CH) 2012-04-18 — — EP claimed
EP-2440536-A1 OXAZOLE AND THIAZOLE DERIVATIVES AS ALX RECEPTOR AGONISTS Actelion Pharmaceuticals Ltd. (CH) 2012-04-18 — — EP disclosed