Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.53 |
| ▸ | CFTR | P13569 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.53 |
| ▸ | GAA | P10253 | 6/20 | 0.53 |
| ▸ | GLA | P06280 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | CASP1 | P29466 | 1/20 | 0.53 |
| ▸ | CASP7 | P55210 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 3/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | NQO2 | P16083 | 3/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA7 | P43166 | 1/20 | 0.43 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL523584 | 0.88 | ABL1 (0.57) | ABL1ALDH1A1HSD17B10CFTRKDM4E | |
| SCHEMBL31280031 | 0.87 | ABL1 (0.59) | ABL1ALDH1A1HSD17B10CFTRKDM4E | |
| SCHEMBL22905002 | 0.87 | ABL1 (0.59) | ABL1ALDH1A1HSD17B10CFTRKDM4E | |
| SCHEMBL3133978 | 0.85 | ABL1 (0.57) | ABL1ALDH1A1HSD17B10CFTRKDM4E | |
| SCHEMBL1578948 | 0.85 | ABL1 (0.57) | ABL1ALDH1A1HSD17B10CFTRKDM4E | |
| SCHEMBL3666380 | 0.85 | ABL1 (0.57) | ABL1ALDH1A1HSD17B10CFTRKDM4E | |
| SCHEMBL23537740 | 0.84 | ABL1 (0.56) | ABL1ALDH1A1HSD17B10CFTRKDM4E | |
| SCHEMBL10514582 | 0.84 | ABL1 (0.56) | ABL1ALDH1A1HSD17B10CFTRKDM4E | |
| SCHEMBL13715480 | 0.84 | ABL1 (0.56) | ABL1ALDH1A1HSD17B10CFTRKDM4E | |
| SCHEMBL903478 | 0.84 | ABL1 (0.56) | ABL1ALDH1A1HSD17B10CFTRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200262850-A1 | SUBSTITUTED ASYMMETRIC UREAS AS MODULATORS OF GHRELIN RECEPTOR ACTIVITY | HELSINN HEALTHCARE SA (CH) | 2020-08-20 | — | — | US | disclosed |
| EP-3114118-B1 | P-SUBSTITUTED ASYMMETRIC UREAS AND MEDICAL USES THEREOF | HELSINN HEALTHCARE SA (CH) | 2020-07-22 | — | — | EP | disclosed |
| US-10577384-B2 | Substituted asymmetric ureas as modulators of ghrelin receptor activity | HELSINN HEALTHCARE SA (CH) | 2020-03-03 | — | — | US | disclosed |
| US-9926337-B2 | Substituted asymmetric ureas as modulators of ghrelin receptor activity | HELSINN HEALTHCARE SA (CH) | 2018-03-27 | — | — | US | disclosed |
| US-20170145038-A1 | SUBSTITUTED ASYMMETRIC UREAS AND MEDICAL USES THEREOF | HELSINN HEALTHCARE SA (CH) | 2017-05-25 | — | — | US | disclosed |
| US-9546157-B2 | Asymmetric piperidinyl-substituted ureas as medicines | HELSINN HEALTHCARE SA (CH) | 2017-01-17 | — | — | US | disclosed |
| WO-2015134839-A1 | P-SUBSTITUTED ASYMMETRIC UREAS AND MEDICAL USES THEREOF | HELSINN HEALTHCARE SA (CH) | 2015-09-11 | — | — | WO | disclosed |
| US-20150252021-A1 | p-Substituted Asymmetric Ureas and Medical Uses Thereof | HELSINN HEALTHCARE SA (CH) | 2015-09-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10577384-B2 | Substituted asymmetric ureas as modulators of ghrelin receptor activity | GHSR, GIPR, UTS2R | ABL1 2984/4885ALDH1A1 3283/4885HSD17B10 2204/4885 |
| US-20150252021-A1 | p-Substituted Asymmetric Ureas and Medical Uses Thereof | UTS2R, GIPR, GPR119 | ABL1 2822/4885ALDH1A1 2353/4885HSD17B10 2601/4885 |
| US-20200262850-A1 | SUBSTITUTED ASYMMETRIC UREAS AS MODULATORS OF GHRELIN RECEPTOR ACTIVITY | GHSR, GIPR, UTS2R | ABL1 2984/4885ALDH1A1 3283/4885HSD17B10 2204/4885 |
| US-20170145038-A1 | SUBSTITUTED ASYMMETRIC UREAS AND MEDICAL USES THEREOF | UTS2R, GHSR, GPR119 | ABL1 2170/4885ALDH1A1 1977/4885HSD17B10 1849/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.