Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | LIPG | Q9Y5X9 | 2/20 | 0.31 |
| ▸ | P4HB | P07237 | 1/20 | 0.31 |
| ▸ | LPL | P06858 | 1/20 | 0.30 |
| ▸ | F2 | P00734 | 1/20 | 0.30 |
| ▸ | F11 | P03951 | 1/20 | 0.30 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.30 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.30 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31386700 | 0.96 | P2RX7 (0.37) | P2RX7MAPK1LIPGP4HBLPL | |
| SCHEMBL20745098 | 0.81 | SLC6A3 (0.38) | P2RX7 | |
| SCHEMBL25251651 | 0.78 | SLC6A3 (0.38) | P2RX7 | |
| SCHEMBL25315269 | 0.74 | KDM4E (0.41) | P2RX7MAPK1 | |
| SCHEMBL2752333 | 0.71 | P2RX7 (0.42) | P2RX7MAPK1LIPGLPL | |
| SCHEMBL17074436 | 0.70 | P2RX7 (0.31) | P2RX7 | |
| SCHEMBL25425499 | 0.67 | P2RX7 (0.42) | P2RX7MAPK1LIPGLPL | |
| SCHEMBL2753751 | 0.67 | P2RX7 (0.39) | P2RX7MAPK1LIPGLPL | |
| SCHEMBL17024327 | 0.66 | DHODH (0.41) | — | |
| SCHEMBL217840 | 0.66 | DHODH (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2367821-B1 | C-RING MODIFIED TRICYCLIC BENZONAPHTHIRIDINONE PROTEIN KINASE INHIBITORS AND USE THEREOF | MERCK PATENT GMBH (DE) | 2015-09-16 | — | — | EP | claimed |