Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | TNF | P01375 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.38 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17074445 | 0.92 | MEN1 (0.43) | MEN1KMT2ALMNAMAPTADORA1 | |
| SCHEMBL2483520 | 0.84 | MEN1 (0.48) | MEN1KMT2ALMNAMAPTADORA1 | |
| SCHEMBL2486254 | 0.82 | MEN1 (0.48) | MEN1KMT2ALMNAMAPTADORA1 | |
| SCHEMBL31288129 | 0.77 | SLC6A5 (0.38) | MEN1KMT2ALMNASIGMAR1NPC1 | |
| SCHEMBL17074443 | 0.73 | CYP3A4 (0.44) | MEN1KMT2ALMNAMAPTADORA1 | |
| SCHEMBL17074434 | 0.73 | CYP3A4 (0.44) | MEN1KMT2ALMNAMAPTADORA1 | |
| SCHEMBL14710355 | 0.68 | OPRM1 (0.46) | KDM4ECYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL4405414 | 0.68 | TMEM97 (0.45) | MEN1KMT2ASMN1; SMN2SIGMAR1CYP3A4 | |
| SCHEMBL6994227 | 0.68 | KMT2A (0.47) | MEN1KMT2ALMNAMAPTADORA1 | |
| SCHEMBL20300563 | 0.67 | MEN1 (0.57) | MEN1KMT2ALMNAMAPTADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2367821-B1 | C-RING MODIFIED TRICYCLIC BENZONAPHTHIRIDINONE PROTEIN KINASE INHIBITORS AND USE THEREOF | MERCK PATENT GMBH (DE) | 2015-09-16 | — | — | EP | claimed |