Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | EBP | Q15125 | 3/20 | 0.40 |
| ▸ | FPR1 | P21462 | 1/20 | 0.40 |
| ▸ | FPR2 | P25090 | 1/20 | 0.40 |
| ▸ | PTGES | O14684 | 2/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 7/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17074592 | 1.00 | HSD11B1 (0.41) | HSD11B1EBPFPR1FPR2PTGES | |
| SCHEMBL549281 | 0.86 | HSD11B1 (0.43) | HSD11B1EBPFPR1FPR2NOTUM | |
| SCHEMBL549280 | 0.86 | HSD11B1 (0.43) | HSD11B1EBPFPR1FPR2NOTUM | |
| SCHEMBL17082140 | 0.84 | HSD11B1 (0.41) | HSD11B1EBPFPR1FPR2PTGES | |
| SCHEMBL550443 | 0.84 | HSD11B1 (0.41) | HSD11B1EBPFPR1FPR2PTGES | |
| SCHEMBL4570105 | 0.84 | HSD11B1 (0.41) | HSD11B1EBPFPR1FPR2PTGES | |
| SCHEMBL550444 | 0.84 | HSD11B1 (0.41) | HSD11B1EBPFPR1FPR2PTGES | |
| SCHEMBL550496 | 0.81 | HSD11B1 (0.41) | HSD11B1EBPFPR1FPR2NOTUM | |
| SCHEMBL17082135 | 0.81 | HSD11B1 (0.41) | HSD11B1EBPFPR1FPR2NOTUM | |
| SCHEMBL550786 | 0.76 | AKR1C3 (0.48) | HSD11B1EBPFPR1FPR2NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1812005-B1 | LACTAM COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORP (US) | 2015-09-16 | — | — | EP | claimed |