Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 17/20 | 0.45 |
| ▸ | HTR2B | P41595 | 9/20 | 0.43 |
| ▸ | HTR2A | P28223 | 6/20 | 0.43 |
| ▸ | HTR6 | P50406 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17075194 | 0.77 | HTR2C (0.46) | HTR2CHTR2BHTR2A | |
| SCHEMBL17075130 | 0.77 | HTR2C (0.59) | HTR2CHTR2BHTR2A | |
| SCHEMBL8268025 | 0.72 | HTR2C (0.62) | HTR2CHTR2BHTR2A | |
| SCHEMBL11884369 | 0.70 | HTR2C (0.50) | HTR2CHTR2BHTR2A | |
| SCHEMBL8266078 | 0.68 | HTR2C (0.66) | HTR2CHTR2BHTR2A | |
| SCHEMBL15522685 | 0.65 | HTR2C (0.63) | HTR2CHTR2BHTR2A | |
| SCHEMBL8267029 | 0.65 | HTR2C (0.62) | HTR2CHTR2BHTR2A | |
| SCHEMBL15522728 | 0.64 | HTR2C (0.50) | HTR2CHTR2BHTR2A | |
| SCHEMBL17075155 | 0.64 | PARP1 (0.39) | HTR2CHTR2BHTR2A | |
| SCHEMBL4354520 | 0.64 | HTR2C (0.64) | HTR2CHTR2BHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3116873-B1 | HEXAHYDRODIAZEPINOQUINOLINES CARRYING A CYCLIC RADICAL | ABBVIE DEUTSCHLAND (DE) | 2018-02-28 | — | — | EP | disclosed |
| US-20170158693-A1 | HEXAHYDRODIAZEPINOQUINOLINES CARRYING A CYCLIC RADICAL | ABBVIE DEUTSCHLAND (DE) | 2017-06-08 | — | — | US | disclosed |
| US-9573950-B2 | Substituted [1,4]diazepino[6,7,1-ij]quinolines as serotonin 5-HT2C receptor modulators | ABBVIE DEUTSCHLAND GMBH & CO KG (DE) | 2017-02-21 | — | — | US | disclosed |
| EP-3116873-A1 | HEXAHYDRODIAZEPINOQUINOLINES CARRYING A CYCLIC RADICAL | AbbVie Deutschland GmbH & Co. KG (DE) | 2017-01-18 | — | — | EP | disclosed |
| US-20150259343-A1 | HEXAHYDRODIAZEPINOQUINOLINES CARRYING A CYCLIC RADICAL | AbbVie Deutschland GmbH & Co. KG (DE) | 2015-09-17 | — | — | US | disclosed |
| WO-2015136090-A1 | HEXAHYDRODIAZEPINOQUINOLINES CARRYING A CYCLIC RADICAL | AbbVie Deutschland GmbH & Co. KG (DE) | 2015-09-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170158693-A1 | HEXAHYDRODIAZEPINOQUINOLINES CARRYING A CYCLIC RADICAL | HTR2C, HTR2A, HTR5A | HTR2C 1/4885HTR2B 8/4885HTR2A 2/4885 |
| US-20150259343-A1 | HEXAHYDRODIAZEPINOQUINOLINES CARRYING A CYCLIC RADICAL | HTR2C, HTR2A, HTR5A | HTR2C 1/4885HTR2B 8/4885HTR2A 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.