Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 16/20 | 0.39 |
| ▸ | HTR2C | P28335 | 4/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 2/20 | 0.31 |
| ▸ | DRD1 | P21728 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17075196 | 0.77 | PARP1 (0.39) | PARP1HTR2CHTR2BHTR2A | |
| SCHEMBL8266332 | 0.76 | HTR2C (0.59) | PARP1HTR2CHTR2BHTR2A | |
| SCHEMBL17075130 | 0.76 | HTR2C (0.59) | HTR2CHTR2BHTR2A | |
| SCHEMBL6202369 | 0.67 | HTR2C (0.53) | PARP1HTR2CHTR2B | |
| SCHEMBL6494486 | 0.65 | HTR2A (0.43) | PARP1HTR2CHTR2ADRD1SLC6A4 | |
| SCHEMBL6494489 | 0.65 | HTR2A (0.43) | PARP1HTR2CHTR2ADRD1SLC6A4 | |
| SCHEMBL17075112 | 0.65 | KDM1A (0.35) | — | |
| SCHEMBL15522686 | 0.64 | MEN1 (0.42) | PARP1HTR2CHTR2BHTR2A | |
| SCHEMBL17075153 | 0.64 | HTR2C (0.45) | HTR2CHTR2BHTR2A | |
| SCHEMBL15522951 | 0.63 | PARP1 (0.36) | PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3116873-B1 | HEXAHYDRODIAZEPINOQUINOLINES CARRYING A CYCLIC RADICAL | ABBVIE DEUTSCHLAND (DE) | 2018-02-28 | — | — | EP | disclosed |
| US-20170158693-A1 | HEXAHYDRODIAZEPINOQUINOLINES CARRYING A CYCLIC RADICAL | ABBVIE DEUTSCHLAND (DE) | 2017-06-08 | — | — | US | disclosed |
| US-9573950-B2 | Substituted [1,4]diazepino[6,7,1-ij]quinolines as serotonin 5-HT2C receptor modulators | ABBVIE DEUTSCHLAND GMBH & CO KG (DE) | 2017-02-21 | — | — | US | disclosed |
| EP-3116873-A1 | HEXAHYDRODIAZEPINOQUINOLINES CARRYING A CYCLIC RADICAL | AbbVie Deutschland GmbH & Co. KG (DE) | 2017-01-18 | — | — | EP | disclosed |
| US-20150259343-A1 | HEXAHYDRODIAZEPINOQUINOLINES CARRYING A CYCLIC RADICAL | AbbVie Deutschland GmbH & Co. KG (DE) | 2015-09-17 | — | — | US | disclosed |
| WO-2015136090-A1 | HEXAHYDRODIAZEPINOQUINOLINES CARRYING A CYCLIC RADICAL | AbbVie Deutschland GmbH & Co. KG (DE) | 2015-09-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170158693-A1 | HEXAHYDRODIAZEPINOQUINOLINES CARRYING A CYCLIC RADICAL | HTR2C, HTR2A, HTR5A | PARP1 1095/4885HTR2C 1/4885HTR2B 8/4885 |
| US-20150259343-A1 | HEXAHYDRODIAZEPINOQUINOLINES CARRYING A CYCLIC RADICAL | HTR2C, HTR2A, HTR5A | PARP1 1095/4885HTR2C 1/4885HTR2B 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.