Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | CASP7 | P55210 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | PRKACA | P17612 | 1/20 | 0.34 |
| ▸ | PRKACG | P22612 | 1/20 | 0.34 |
| ▸ | PRKACB | P22694 | 1/20 | 0.34 |
| ▸ | RBP4 | P02753 | 2/20 | 0.33 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17075236 | 0.82 | CYP2C19 (0.40) | CYP2C19TEAD1ALDH1A1MAPTKDM4E | |
| SCHEMBL17075230 | 0.80 | HTR2A (0.34) | TEAD1ALDH1A1MEN1ALOX15KMT2A | |
| SCHEMBL17075184 | 0.77 | ALDH1A1 (0.39) | CYP2C19TEAD1ALDH1A1MAPTKDM4E | |
| SCHEMBL17075141 | 0.76 | ALDH1A1 (0.39) | CYP2C19ALDH1A1MAPTKDM4EMEN1 | |
| SCHEMBL17075119 | 0.76 | ALDH1A1 (0.40) | CYP2C19ALDH1A1MAPTKDM4EMEN1 | |
| SCHEMBL17075110 | 0.73 | ALDH1A1 (0.36) | CYP2C19TEAD1ALDH1A1MAPTKDM4E | |
| SCHEMBL17075131 | 0.73 | ALDH1A1 (0.38) | CYP2C19ALDH1A1MAPTKDM4EMEN1 | |
| SCHEMBL17075125 | 0.71 | ALDH1A1 (0.39) | CYP2C19ALDH1A1MAPTKDM4EMEN1 | |
| SCHEMBL17075104 | 0.70 | ALDH1A1 (0.38) | CYP2C19ALDH1A1MAPTKDM4EMEN1 | |
| SCHEMBL17075092 | 0.69 | TMEM97 (0.38) | CYP2C19ALDH1A1MAPTKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3116874-B1 | HEXAHYDRODIAZEPINOQUINOLINES CARRYING A SUBSTITUTED ALKYL RADICAL | ABBVIE DEUTSCHLAND (DE) | 2018-02-28 | — | — | EP | disclosed |
| US-20170112851-A1 | HEXAHYDRODIAZEPINOQUINOLINES CARRYING A SUBSTITUTED ALKYL RADICAL | AbbVie Deutschland GmbH & Co. KG (DE) | 2017-04-27 | — | — | US | disclosed |
| US-9540376-B2 | Hexahydrodiazepinoquinolines carrying a substituted alkyl radical | AbbVie Deutschland GmbH & Co. KG (DE) | 2017-01-10 | — | — | US | disclosed |
| US-20150259346-A1 | HEXAHYDRODIAZEPINOQUINOLINES CARRYING A SUBSTITUTED ALKYL RADICAL | AbbVie Deutschland GmbH & Co. KG (DE) | 2015-09-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170112851-A1 | HEXAHYDRODIAZEPINOQUINOLINES CARRYING A SUBSTITUTED ALKYL RADICAL | HTR2C, HTR2A, HTR3C | CYP2C19 110/4885TEAD1 3351/4885ALDH1A1 866/4885 |
| US-20150259346-A1 | HEXAHYDRODIAZEPINOQUINOLINES CARRYING A SUBSTITUTED ALKYL RADICAL | HTR2C, HTR2A, HTR3C | CYP2C19 110/4885TEAD1 3351/4885ALDH1A1 866/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.