Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.58 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | NT5E | P21589 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.40 |
| ▸ | IP6K3 | Q96PC2 | 1/20 | 0.40 |
| ▸ | IP6K2 | Q9UHH9 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17075413 | 0.96 | MEN1 (0.54) | MEN1KMT2AALDH1A1HPGDNPC1 | |
| SCHEMBL15556697 | 0.96 | MEN1 (0.54) | MEN1KMT2AALDH1A1HPGDNPC1 | |
| SCHEMBL15556997 | 0.94 | ALDH1A1 (0.65) | MEN1KMT2AALDH1A1HPGDNPC1 | |
| SCHEMBL15556946 | 0.94 | MEN1 (0.53) | MEN1KMT2AALDH1A1HPGDNPC1 | |
| SCHEMBL15557174 | 0.94 | MEN1 (0.53) | MEN1KMT2AALDH1A1HPGDNPC1 | |
| SCHEMBL17075416 | 0.89 | ALDH1A1 (0.49) | MEN1KMT2AALDH1A1HPGDNPC1 | |
| SCHEMBL17075423 | 0.86 | ALDH1A1 (0.52) | MEN1KMT2AALDH1A1HPGDNPC1 | |
| SCHEMBL15556696 | 0.85 | MEN1 (0.52) | MEN1KMT2AALDH1A1HPGDNPC1 | |
| SCHEMBL15556017 | 0.84 | MEN1 (0.52) | MEN1KMT2AALDH1A1HPGDNPC1 | |
| SCHEMBL17075427 | 0.84 | ALDH1A1 (0.52) | MEN1KMT2AALDH1A1HPGDNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9440962-B2 | Benzisoxazoles | HOFFMANN-LA ROCHE INC. (US) | 2016-09-13 | — | — | US | claimed |
| EP-2877466-B1 | BENZISOXAZOLE MODULATORS OF NEUROGENESIS | HOFFMANN LA ROCHE (CH) | 2016-07-06 | — | — | EP | claimed |
| US-9440962-B2 | Benzisoxazoles | HOFFMANN-LA ROCHE INC. (US) | 2016-09-13 | — | — | US | disclosed |
| US-9440962-B2 | Benzisoxazoles | HOFFMANN-LA ROCHE INC. (US) | 2016-09-13 | — | — | US | disclosed |
| US-9440962-B2 | Benzisoxazoles | HOFFMANN-LA ROCHE INC. (US) | 2016-09-13 | — | — | US | disclosed |
| EP-2877466-B1 | BENZISOXAZOLE MODULATORS OF NEUROGENESIS | HOFFMANN LA ROCHE (CH) | 2016-07-06 | — | — | EP | disclosed |
| EP-2877466-B1 | BENZISOXAZOLE MODULATORS OF NEUROGENESIS | HOFFMANN LA ROCHE (CH) | 2016-07-06 | — | — | EP | disclosed |
| US-20150259334-A1 | BENZISOXAZOLES | HOFFMANN-LA ROCHE INC. (US) | 2015-09-17 | — | — | US | disclosed |
| US-20150259334-A1 | BENZISOXAZOLES | HOFFMANN-LA ROCHE INC. (US) | 2015-09-17 | — | — | US | disclosed |
| US-20150259334-A1 | BENZISOXAZOLES | HOFFMANN-LA ROCHE INC. (US) | 2015-09-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150259334-A1 | BENZISOXAZOLES | CDR2, CHRNA5, CHRNA3 | MEN1 1009/4885KMT2A 3915/4885ALDH1A1 239/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.