Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.64 |
| ▸ | F13A1 | P00488 | 1/20 | 0.56 |
| ▸ | TGM2 | P21980 | 1/20 | 0.56 |
| ▸ | TGM1 | P22735 | 1/20 | 0.56 |
| ▸ | NR1H2 | P55055 | 9/20 | 0.45 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.43 |
| ▸ | NR1H3 | Q13133 | 7/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | SPR | P35270 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17075769 | 1.00 | HSD11B1 (0.64) | HSD11B1F13A1TGM2TGM1NR1H2 | |
| SCHEMBL15932400 | 1.00 | HSD11B1 (0.64) | HSD11B1F13A1TGM2TGM1NR1H2 | |
| SCHEMBL31472006 | 0.85 | HSD11B1 (0.79) | HSD11B1F13A1TGM2TGM1NR1H2 | |
| SCHEMBL15915309 | 0.84 | HSD11B1 (0.43) | HSD11B1F13A1TGM2TGM1EPHX2 | |
| SCHEMBL15918371 | 0.84 | HSD11B1 (0.43) | HSD11B1F13A1TGM2TGM1EPHX2 | |
| SCHEMBL30121356 | 0.84 | HSD11B1 (0.81) | HSD11B1F13A1TGM2TGM1NR1H2 | |
| SCHEMBL31471867 | 0.84 | HSD11B1 (0.61) | HSD11B1F13A1TGM2TGM1NR1H2 | |
| SCHEMBL31471842 | 0.81 | HSD11B1 (0.76) | HSD11B1F13A1TGM2TGM1PARP1 | |
| SCHEMBL31471811 | 0.80 | HSD11B1 (0.64) | HSD11B1F13A1TGM2TGM1NR1H2 | |
| SCHEMBL1618371 | 0.79 | HSD11B1 (0.70) | HSD11B1F13A1TGM2TGM1NR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9884878-B2 | FLAP modulators | JANSSEN PHARMACEUTICA NV (BE) | 2018-02-06 | — | — | US | disclosed |
| US-20150259357-A1 | FLAP MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2015-09-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150259357-A1 | FLAP MODULATORS | PGF, FEN1, TBXA2R | HSD11B1 203/4885F13A1 260/4885TGM2 3461/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.