Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 5/20 | 0.43 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.40 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.40 |
| ▸ | HPGDS | O60760 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | VCP | P55072 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17077311 | 1.00 | GRIN2B (0.43) | GRIN2BKDM2BDRD2DRD4DRD3 | |
| SCHEMBL16986225 | 0.85 | HPGDS (0.43) | GRIN2BKDM2BDRD2DRD4DRD3 | |
| SCHEMBL16986223 | 0.85 | HPGDS (0.43) | GRIN2BKDM2BDRD2DRD4DRD3 | |
| SCHEMBL15830635 | 0.84 | DRD2 (0.50) | KDM2BDRD2DRD4DRD3NPC1 | |
| SCHEMBL16995034 | 0.83 | JAK1 (0.45) | HPGDS | |
| SCHEMBL15824772 | 0.80 | KDM2B (0.49) | KDM2BDRD2DRD4DRD3LMNA | |
| SCHEMBL16986289 | 0.76 | KDM2B (0.41) | GRIN2BKDM2BDRD2DRD4DRD3 | |
| SCHEMBL16986291 | 0.76 | KDM2B (0.41) | GRIN2BKDM2BDRD2DRD4DRD3 | |
| SCHEMBL30716678 | 0.76 | DRD2 (0.43) | KDM2BDRD2DRD4DRD3TP53 | |
| SCHEMBL16986292 | 0.75 | SSTR4 (0.41) | GRIN2BKDM2BDRD2DRD4DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150259344-A1 | IMIDAZOLE DERIVATIVE | SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) | 2015-09-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150259344-A1 | IMIDAZOLE DERIVATIVE | CHRNA4, CHRNB4, CHRNA7 | GRIN2B 88/4885KDM2B 628/4885DRD2 581/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.