Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 1/20 | 0.32 |
| ▸ | AKT1S1 | Q96B36 | 1/20 | 0.31 |
| ▸ | DHFR | P00374 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30278034 | 0.71 | DHFR (0.34) | DHFR | |
| SCHEMBL30278050 | 0.66 | DHFR (0.32) | DHFR | |
| SCHEMBL30412014 | 0.66 | AR (0.39) | DHFR | |
| SCHEMBL30278060 | 0.63 | DHFR (0.33) | DHFR | |
| SCHEMBL17362435 | 0.62 | RET (0.46) | RETAKT1S1 | |
| SCHEMBL30698015 | 0.61 | GRM5 (0.40) | DHFR | |
| SCHEMBL30698038 | 0.61 | GRM5 (0.40) | DHFR | |
| SCHEMBL24175682 | 0.60 | RET (0.32) | RET | |
| SCHEMBL24568075 | 0.59 | RET (0.33) | RET | |
| SCHEMBL17077911 | 0.58 | GRM5 (0.38) | RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015138689-A1 | FUSED MORPHOLINOPYRIMIDINES AND METHODS OF USE THEREOF | FORUM PHARMACEUTICALS INC. (US) | 2015-09-17 | — | — | WO | disclosed |