Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 7/20 | 0.42 |
| ▸ | SDHB | P21912 | 7/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | STAT3 | P40763 | 2/20 | 0.40 |
| ▸ | STAT1 | P42224 | 2/20 | 0.40 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15650100 | 0.77 | RIPK2 (0.32) | — | |
| SCHEMBL17079133 | 0.77 | HSP90AA1 (0.41) | PTGS2HSD17B10KMT2AHSP90AA1HSP90AB1 | |
| SCHEMBL17079132 | 0.75 | NOS3 (0.47) | LMNAHSD17B10HPGDKMT2AHSP90AA1 | |
| SCHEMBL17085390 | 0.75 | HSP90AA1 (0.40) | HSD17B10KMT2AHSP90AA1HSP90AB1ALDH1A1 | |
| SCHEMBL19004924 | 0.75 | HSP90AA1 (0.40) | HSD17B10HTTKMT2AMEN1HSP90AA1 | |
| Bromide SCHEMBL18985550 | 0.74 | HSP90AA1 (0.39) | HSD17B10KMT2AHSP90AA1HSP90AB1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL17079135 | 0.74 | LOXL2 (0.40) | HSD17B10KMT2AHSP90AA1HSP90AB1ALDH1A1 | |
| SCHEMBL2376297 | 0.71 | IDO1 (0.44) | KMT2AMEN1 | |
| SCHEMBL24027029 | 0.70 | HRH3 (0.39) | NPSR1KMT2AHSP90AA1HSP90AB1ALDH1A1 | |
| SCHEMBL18050066 | 0.70 | TSHR (0.40) | PTGS2TP53POLBHSP90AA1HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9856242-B2 | 5-fluoro-N-(pyridin-2-yl)pyridin-2-amine derivatives containing a sulfone group | BAYER PHARMA AKTIENGESELLSCAFT (DE) | 2018-01-02 | — | — | US | disclosed |
| US-9856242-B2 | 5-fluoro-N-(pyridin-2-yl)pyridin-2-amine derivatives containing a sulfone group | BAYER PHARMA AKTIENGESELLSCAFT (DE) | 2018-01-02 | — | — | US | disclosed |
| EP-3116869-A1 | 5-FLUORO-N-(PYRIDIN-2-YL)PYRIDIN-2-AMINE DERIVATIVES CONTAINING A SULFONE GROUP | Bayer Pharma Aktiengesellschaft (DE) | 2017-01-18 | — | — | EP | disclosed |
| US-20170001989-A1 | 5-FLUORO-N-(PYRIDIN-2-YL)PYRIDIN-2-AMINE DERIVATIVES CONTAINING A SULFONE GROUP | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2017-01-05 | — | — | US | disclosed |
| US-20170001989-A1 | 5-FLUORO-N-(PYRIDIN-2-YL)PYRIDIN-2-AMINE DERIVATIVES CONTAINING A SULFONE GROUP | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2017-01-05 | — | — | US | disclosed |
| US-20170001989-A1 | 5-FLUORO-N-(PYRIDIN-2-YL)PYRIDIN-2-AMINE DERIVATIVES CONTAINING A SULFONE GROUP | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2017-01-05 | — | — | US | disclosed |
| CN-106232596-A | 5 fluorine N (pyridine 2 base) pyridine 2 amine derivative containing sulfone group | 拜耳医药股份有限公司 | 2016-12-14 | — | — | CN | disclosed |
| WO-2015136028-A1 | 5-FLUORO-N-(PYRIDIN-2-YL)PYRIDIN-2-AMINE DERIVATIVES CONTAINING A SULFONE GROUP | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2015-09-17 | — | — | WO | disclosed |
| WO-2015136028-A1 | 5-FLUORO-N-(PYRIDIN-2-YL)PYRIDIN-2-AMINE DERIVATIVES CONTAINING A SULFONE GROUP | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2015-09-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170001989-A1 | 5-FLUORO-N-(PYRIDIN-2-YL)PYRIDIN-2-AMINE DERIVATIVES CONTAINING A SULFONE GROUP | PNPO, PAH, TPMT | PTGS2 1220/4885SDHB 16/4885LMNA 490/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.