Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1708709 | 0.99 | SMN1; SMN2 (0.33) | SMN1; SMN2HSD17B10MAPTMAPK1ALDH1A1 | |
| SCHEMBL10010075 | 0.85 | PPARG (0.41) | — | |
| SCHEMBL3718064 | 0.85 | BACE1 (0.30) | — | |
| SCHEMBL3718334 | 0.84 | PPARG (0.33) | — | |
| SCHEMBL1708712 | 0.79 | FFAR1 (0.33) | — | |
| SCHEMBL1707824 | 0.78 | NPC1 (0.37) | SMN1; SMN2MAPTMAPK1 | |
| SCHEMBL10011908 | 0.76 | FFAR1 (0.42) | — | |
| SCHEMBL3716544 | 0.76 | HTR2A (0.33) | SMN1; SMN2HSD17B10MAPTMAPK1ALDH1A1 | |
| SCHEMBL10009300 | 0.74 | PPARD (0.39) | — | |
| SCHEMBL1708698 | 0.73 | MAPT (0.35) | SMN1; SMN2MAPTMAPK1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2440541-A1 | NOVEL FUSED CYCLIC COMPOUND AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2012-04-18 | — | — | EP | disclosed |
| WO-2010143733-A1 | NOVEL FUSED CYCLIC COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-12-16 | — | — | WO | disclosed |