Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FPR2 | P25090 | 2/20 | 0.46 |
| ▸ | FPR1 | P21462 | 1/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 8/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17079984 | 0.81 | ROCK2 (0.45) | FPR2FPR1ROCK2 | |
| SCHEMBL17079989 | 0.81 | ROCK2 (0.59) | FPR2FPR1ROCK2HDAC1HDAC8 | |
| SCHEMBL17079979 | 0.80 | ROCK2 (0.51) | FPR2FPR1ROCK2MEN1KMT2A | |
| SCHEMBL17080030 | 0.76 | ROCK2 (0.39) | ROCK2CA12CA1CA2CA9 | |
| SCHEMBL17080091 | 0.74 | FPR2 (0.50) | FPR2FPR1ROCK2HDAC6MEN1 | |
| SCHEMBL17080094 | 0.74 | MAPT (0.43) | FPR2FPR1ROCK2MEN1KMT2A | |
| SCHEMBL17080055 | 0.73 | ROCK2 (0.46) | FPR2FPR1ROCK2 | |
| SCHEMBL16468325 | 0.72 | ROCK2 (0.48) | FPR2FPR1ROCK2HDAC1HDAC8 | |
| SCHEMBL17080069 | 0.71 | ROCK2 (0.46) | FPR2FPR1ROCK2 | |
| SCHEMBL17080007 | 0.71 | ROCK2 (0.49) | FPR2FPR1ROCK2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3116877-A1 | CHEMICAL COMPOUNDS ACTING AS PERK INHIBITORS | Glaxosmithkline Intellectual Property (No. 2) Limited (GB) | 2017-01-18 | — | — | EP | disclosed |
| WO-2015136463-A1 | CHEMICAL COMPOUNDS ACTING AS PERK INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2015-09-17 | — | — | WO | disclosed |
| WO-2015136463-A1 | CHEMICAL COMPOUNDS ACTING AS PERK INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2015-09-17 | — | — | WO | disclosed |