Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 4/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | HPGDS | O60760 | 1/20 | 0.33 |
| ▸ | ALKBH2 | Q6NS38 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 3/20 | 0.31 |
| ▸ | TSHR | P16473 | 3/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL796144 | 0.68 | NOTUM (0.43) | NOTUMGAAP2RX7HPGDKDM4E | |
| SCHEMBL430176 | 0.65 | GAA (0.42) | NOTUMGAAP2RX7HPGDKDM4E | |
| SCHEMBL69609 | 0.64 | NOTUM (0.39) | NOTUMGAAP2RX7HPGDKDM4E | |
| SCHEMBL496797 | 0.64 | NOTUM (0.43) | NOTUMGAAP2RX7HPGDKDM4E | |
| SCHEMBL28777159 | 0.62 | ADORA1 (0.40) | NOTUMGAAHPGDKDM4EL3MBTL1 | |
| SCHEMBL4717229 | 0.61 | GAA (0.47) | NOTUMGAAP2RX7HPGDKDM4E | |
| SCHEMBL274416 | 0.61 | NOTUM (0.39) | NOTUMGAAP2RX7KDM4EL3MBTL1 | |
| SCHEMBL1901000 | 0.61 | NPC1 (0.39) | NOTUMGAAHPGDKDM4EL3MBTL1 | |
| SCHEMBL1323074 | 0.60 | PTGS2 (0.42) | NOTUMP2RX7HPGDKDM4EHSD17B10 | |
| SCHEMBL698253 | 0.59 | KDM4E (0.43) | NOTUMGAAP2RX7HPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015135094-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2015-09-17 | — | — | WO | disclosed |