Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNC | P24863 | 2/20 | 0.41 |
| ▸ | CDK8 | P49336 | 2/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.39 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | THPO | P40225 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL550119 | 1.00 | CCNC (0.41) | CCNCCDK8P2RX7OPRM1OPRL1 | |
| SCHEMBL549518 | 0.91 | CCNC (0.39) | CCNCCDK8P2RX7OPRM1OPRL1 | |
| SCHEMBL17082058 | 0.91 | CCNC (0.39) | CCNCCDK8P2RX7OPRM1OPRL1 | |
| SCHEMBL17082044 | 0.90 | P2RX7 (0.41) | CCNCCDK8P2RX7OPRM1OPRL1 | |
| SCHEMBL550776 | 0.90 | P2RX7 (0.41) | CCNCCDK8P2RX7OPRM1OPRL1 | |
| SCHEMBL549835 | 0.88 | HSD11B1 (0.45) | MALT1EGLN1HSD11B1 | |
| SCHEMBL17082064 | 0.88 | HSD11B1 (0.45) | MALT1EGLN1HSD11B1 | |
| SCHEMBL4570053 | 0.81 | MALT1 (0.52) | OPRL1MALT1EGLN1HSD11B1 | |
| SCHEMBL550273 | 0.79 | HSD11B1 (0.44) | MALT1EGLN1HTR1AHTR7ALDH1A1 | |
| SCHEMBL17082059 | 0.79 | HSD11B1 (0.44) | MALT1EGLN1HTR1AHTR7ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1812005-B1 | LACTAM COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORP (US) | 2015-09-16 | — | — | EP | disclosed |