Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.43 |
| ▸ | RAB9A | P51151 | 6/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 6/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 6/20 | 0.40 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.40 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 5/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL549509 | 1.00 | SMN1; SMN2 (0.43) | SMN1; SMN2ALDH1A1RAB9AKDM4EMAPK1 | |
| SCHEMBL549913 | 0.91 | CRBN (0.42) | SMN1; SMN2ALDH1A1RAB9AKDM4EMAPK1 | |
| SCHEMBL17081985 | 0.91 | CRBN (0.42) | SMN1; SMN2ALDH1A1RAB9AKDM4EMAPK1 | |
| SCHEMBL17082015 | 0.81 | CRBN (0.42) | ALDH1A1RAB9AKDM4ECRBNNPSR1 | |
| SCHEMBL4570055 | 0.81 | CRBN (0.42) | ALDH1A1RAB9AKDM4ECRBNNPSR1 | |
| SCHEMBL549536 | 0.81 | HSD11B1 (0.41) | ALDH1A1CRBNMAPTHSD11B1TSHR | |
| SCHEMBL2704081 | 0.81 | HSD11B1 (0.41) | ALDH1A1CRBNMAPTHSD11B1TSHR | |
| SCHEMBL2701119 | 0.81 | CRBN (0.44) | SMN1; SMN2RAB9ACRBNMAPTHTT | |
| SCHEMBL3700460 | 0.81 | CRBN (0.44) | SMN1; SMN2RAB9ACRBNMAPTHTT | |
| SCHEMBL5930600 | 0.81 | CRBN (0.44) | SMN1; SMN2RAB9ACRBNMAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1812005-B1 | LACTAM COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORP (US) | 2015-09-16 | — | — | EP | disclosed |