Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 1/20 | 0.42 |
| ▸ | DGAT1 | O75907 | 7/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.36 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.36 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.36 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.36 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4570055 | 1.00 | CRBN (0.42) | CRBNDGAT1RAB9ANPY5RALDH1A1 | |
| SCHEMBL17082004 | 0.94 | SMN1; SMN2 (0.41) | CRBNDGAT1RAB9ANPY5RALDH1A1 | |
| SCHEMBL4570056 | 0.94 | SMN1; SMN2 (0.41) | CRBNDGAT1RAB9ANPY5RALDH1A1 | |
| SCHEMBL17082048 | 0.92 | CRBN (0.44) | CRBNDGAT1RAB9ANPY5RALDH1A1 | |
| SCHEMBL4570054 | 0.92 | CRBN (0.44) | CRBNDGAT1RAB9ANPY5RALDH1A1 | |
| SCHEMBL2701119 | 0.89 | CRBN (0.44) | CRBNDGAT1RAB9ANPY5RLMNA | |
| SCHEMBL3700460 | 0.89 | CRBN (0.44) | CRBNDGAT1RAB9ANPY5RLMNA | |
| SCHEMBL5930600 | 0.89 | CRBN (0.44) | CRBNDGAT1RAB9ANPY5RLMNA | |
| SCHEMBL549509 | 0.81 | SMN1; SMN2 (0.43) | CRBNRAB9AALDH1A1KDM4ELMNA | |
| SCHEMBL17081986 | 0.81 | SMN1; SMN2 (0.43) | CRBNRAB9AALDH1A1KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1812005-B1 | LACTAM COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORP (US) | 2015-09-16 | — | — | EP | disclosed |