Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 9/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.37 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.36 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.33 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL550677 | 1.00 | EGLN1 (0.40) | EGLN1MAPTKCNJ1MALT1DDB1 | |
| SCHEMBL549480 | 0.85 | MALT1 (0.41) | EGLN1MAPTMALT1DDB1CRBN | |
| SCHEMBL17081994 | 0.85 | MALT1 (0.41) | EGLN1MAPTMALT1DDB1CRBN | |
| SCHEMBL4570093 | 0.82 | EGLN1 (0.38) | EGLN1MALT1DDB1CRBNHCRTR2 | |
| SCHEMBL4570053 | 0.79 | MALT1 (0.52) | EGLN1MALT1 | |
| SCHEMBL2699628 | 0.76 | DRD2 (0.46) | EGLN1MAPTMALT1 | |
| SCHEMBL2699735 | 0.76 | DRD2 (0.46) | EGLN1MAPTMALT1 | |
| SCHEMBL550621 | 0.76 | DRD2 (0.46) | EGLN1MAPTMALT1 | |
| SCHEMBL549652 | 0.75 | EGLN1 (0.38) | EGLN1MAPTMALT1DDB1CRBN | |
| SCHEMBL17081991 | 0.75 | EGLN1 (0.38) | EGLN1MAPTMALT1DDB1CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1812005-B1 | LACTAM COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORP (US) | 2015-09-16 | — | — | EP | disclosed |