Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.46 |
| ▸ | HTR2A | P28223 | 4/20 | 0.46 |
| ▸ | HTR1A | P08908 | 2/20 | 0.44 |
| ▸ | HTR7 | P34969 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.40 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.40 |
| ▸ | MALT1 | Q9UDY8 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2699628 | 1.00 | DRD2 (0.46) | DRD2HTR2AHTR1AHTR7KDM4E | |
| SCHEMBL550621 | 1.00 | DRD2 (0.46) | DRD2HTR2AHTR1AHTR7KDM4E | |
| SCHEMBL549835 | 0.89 | HSD11B1 (0.45) | HSD11B1EGLN1MALT1 | |
| SCHEMBL17082064 | 0.89 | HSD11B1 (0.45) | HSD11B1EGLN1MALT1 | |
| SCHEMBL4570053 | 0.86 | MALT1 (0.52) | HSD11B1EGLN1MALT1 | |
| SCHEMBL550273 | 0.84 | HSD11B1 (0.44) | HTR1AHTR7HSD11B1EGLN1MALT1 | |
| SCHEMBL17082059 | 0.84 | HSD11B1 (0.44) | HTR1AHTR7HSD11B1EGLN1MALT1 | |
| SCHEMBL5572908 | 0.83 | HSD11B1 (0.43) | HSD11B1EGLN1MALT1 | |
| SCHEMBL4570051 | 0.83 | HSD11B1 (0.41) | HSD11B1EGLN1MALT1ALDH1A1MAPT | |
| SCHEMBL549493 | 0.83 | HSD11B1 (0.43) | HSD11B1EGLN1MALT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2450351-A1 | Lactam compounds and their use as pharmaceuticals | Incyte Corporation (US) | 2012-05-09 | — | — | EP | disclosed |