Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | AGPAT2 | O15120 | 8/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | NPY2R | P49146 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4570209 | 1.00 | ALDH1A1 (0.38) | ALDH1A1HPGDCYP1A2CYP2D6CYP2C9 | |
| SCHEMBL4570037 | 0.92 | KMT2A (0.35) | ALDH1A1HPGDCYP1A2CYP2D6CYP2C9 | |
| SCHEMBL4570214 | 0.89 | ALDH1A1 (0.39) | ALDH1A1HPGDCYP1A2CYP2D6CYP2C9 | |
| SCHEMBL17082147 | 0.89 | ALDH1A1 (0.39) | ALDH1A1HPGDCYP1A2CYP2D6CYP2C9 | |
| SCHEMBL4570097 | 0.89 | ALK (0.35) | CYP2C9AGPAT2MAPT | |
| SCHEMBL4570215 | 0.88 | SMN1; SMN2 (0.43) | ALDH1A1HPGDCYP1A2CYP2D6CYP2C9 | |
| SCHEMBL17082193 | 0.88 | SMN1; SMN2 (0.43) | ALDH1A1HPGDCYP1A2CYP2D6CYP2C9 | |
| SCHEMBL4570034 | 0.88 | SMN1; SMN2 (0.39) | ALDH1A1HPGDCYP1A2CYP2D6CYP2C9 | |
| SCHEMBL4570213 | 0.87 | KDM4E (0.41) | ALDH1A1HPGDTSHRHSD11B1KDM4E | |
| SCHEMBL4570228 | 0.87 | MALT1 (0.34) | ALDH1A1HPGDCYP1A2CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1812005-B1 | LACTAM COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORP (US) | 2015-09-16 | — | — | EP | disclosed |