Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 8/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 6/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 8/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.40 |
| ▸ | MEN1 | O00255 | 5/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 4/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | SLC6A7 | Q99884 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL549513 | 1.00 | USP2 (0.41) | USP2ALDH1A1CYP2C9HSD17B10CYP1A2 | |
| SCHEMBL549514 | 1.00 | USP2 (0.41) | USP2ALDH1A1CYP2C9HSD17B10CYP1A2 | |
| SCHEMBL550354 | 0.94 | AKR1C3 (0.46) | USP2ALDH1A1CYP2C9CYP1A2CYP2C19 | |
| SCHEMBL550355 | 0.94 | AKR1C3 (0.46) | USP2ALDH1A1CYP2C9CYP1A2CYP2C19 | |
| SCHEMBL549159 | 0.88 | AKR1C3 (0.52) | ALDH1A1HPGDSMN1; SMN2MEN1KMT2A | |
| SCHEMBL549158 | 0.88 | AKR1C3 (0.52) | ALDH1A1HPGDSMN1; SMN2MEN1KMT2A | |
| SCHEMBL17082145 | 0.88 | AKR1C3 (0.52) | ALDH1A1HPGDSMN1; SMN2MEN1KMT2A | |
| SCHEMBL550896 | 0.87 | AKR1C3 (0.46) | ALDH1A1CYP2C9CYP2C19HPGDMAPK1 | |
| SCHEMBL4570118 | 0.86 | AKR1C3 (0.37) | ALDH1A1HPGDSMN1; SMN2AKR1C3HRH3 | |
| SCHEMBL549394 | 0.86 | CTSS (0.39) | ALDH1A1HPGDSMN1; SMN2AKR1C3TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1812005-B1 | LACTAM COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORP (US) | 2015-09-16 | — | — | EP | disclosed |