Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.35 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4570056 | 1.00 | SMN1; SMN2 (0.41) | SMN1; SMN2TP53HPGDCRBNTRPV1 | |
| SCHEMBL4570055 | 0.94 | CRBN (0.42) | CRBNTRPV1RAB9AALDH1A1TSHR | |
| SCHEMBL17082015 | 0.94 | CRBN (0.42) | CRBNTRPV1RAB9AALDH1A1TSHR | |
| SCHEMBL4570054 | 0.90 | CRBN (0.44) | SMN1; SMN2HPGDCRBNTRPV1RAB9A | |
| SCHEMBL17082048 | 0.90 | CRBN (0.44) | SMN1; SMN2HPGDCRBNTRPV1RAB9A | |
| SCHEMBL2701119 | 0.86 | CRBN (0.44) | SMN1; SMN2CRBNRAB9APOLBMAPT | |
| SCHEMBL5930600 | 0.86 | CRBN (0.44) | SMN1; SMN2CRBNRAB9APOLBMAPT | |
| SCHEMBL3700460 | 0.86 | CRBN (0.44) | SMN1; SMN2CRBNRAB9APOLBMAPT | |
| SCHEMBL17082171 | 0.80 | CRBN (0.44) | SMN1; SMN2TP53HPGDCRBNTRPV1 | |
| SCHEMBL4570144 | 0.80 | CRBN (0.44) | SMN1; SMN2TP53HPGDCRBNTRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1812005-B1 | LACTAM COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORP (US) | 2015-09-16 | — | — | EP | disclosed |