Sugi Predict

Sugi Predict / Compounds / SCHEMBL4570144

SCHEMBL4570144

SCHEMBL4570144

CCCOC(=O)Nc1ccc(N2CCC[C@]3(CCN([C@H]4CC[C@H](O)CC4)C3=O)C2)nc1

nearest known ligand 0.44

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ CRBN Q96SW2 4/20 0.44
▸ SMN1; SMN2 Q16637 4/20 0.43
▸ TP53 P04637 2/20 0.43
▸ HPGD P15428 1/20 0.43
▸ TRPV1 Q8NER1 2/20 0.38
▸ NPC1 O15118 2/20 0.38
▸ MAPT P10636 2/20 0.38
▸ RAB9A P51151 2/20 0.38
▸ NFKB1 P19838 1/20 0.38
▸ NFKB2 Q00653 1/20 0.38
▸ KMT2A Q03164 1/20 0.38
▸ RELA Q04206 1/20 0.38
▸ DDB1 Q16531 1/20 0.37
▸ PDE7A Q13946 2/20 0.37
▸ DGAT1 O75907 7/20 0.35
▸ ALDH1A1 P00352 1/20 0.33
▸ MAPK1 P28482 1/20 0.33
▸ PIK3CA P42336 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17082171 1.00 CRBN (0.44) CRBNSMN1; SMN2TP53HPGDTRPV1
SCHEMBL17082009 0.93 CRBN (0.45) CRBNTRPV1NPC1MAPTRAB9A
SCHEMBL4570143 0.93 CRBN (0.45) CRBNTRPV1NPC1MAPTRAB9A
SCHEMBL10112739 0.92 SMN1; SMN2 (0.41) CRBNSMN1; SMN2TP53HPGDTRPV1
SCHEMBL4570061 0.92 SMN1; SMN2 (0.43) CRBNSMN1; SMN2TP53HPGDTRPV1
SCHEMBL17082010 0.92 SMN1; SMN2 (0.43) CRBNSMN1; SMN2TP53HPGDTRPV1
SCHEMBL4570142 0.90 CRBN (0.48) CRBNTP53HPGDTRPV1MAPT
SCHEMBL17082114 0.90 CRBN (0.48) CRBNTP53HPGDTRPV1MAPT
SCHEMBL17082122 0.89 CRBN (0.43) CRBNSMN1; SMN2TRPV1DDB1PDE7A
SCHEMBL4570141 0.89 CRBN (0.43) CRBNSMN1; SMN2TRPV1DDB1PDE7A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20120122858-A1 LACTAM COMPOUNDS AND THEIR USE AS PHARMACEUTICALS INCYTE CORPORATION (US) 2012-05-17 — — US disclosed
US-20120122858-A1 LACTAM COMPOUNDS AND THEIR USE AS PHARMACEUTICALS INCYTE CORPORATION (US) 2012-05-17 — — US disclosed
US-8110581-B2 Lactam compounds and their use as pharmaceuticals INCYTE CORPORATION (US) 2012-02-07 — — US disclosed
US-8110581-B2 Lactam compounds and their use as pharmaceuticals INCYTE CORPORATION (US) 2012-02-07 — — US disclosed
US-20090291946-A1 LACTAM COMPOUNDS AND THEIR USE AS PHARMACEUTICALS INCYTE CORPORATION (US) 2009-11-26 — — US disclosed
US-20090291946-A1 LACTAM COMPOUNDS AND THEIR USE AS PHARMACEUTICALS INCYTE CORPORATION (US) 2009-11-26 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090291946-A1 LACTAM COMPOUNDS AND THEIR USE AS PHARMACEUTICALS HSD11B1, HSD11B2, HSD17B1 CRBN 2898/4885SMN1; SMN2 3517/4885TP53 4797/4885
US-20120122858-A1 LACTAM COMPOUNDS AND THEIR USE AS PHARMACEUTICALS HSD11B1, HSD11B2, HSD17B1 CRBN 2898/4885SMN1; SMN2 3517/4885TP53 4797/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.