Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 2/20 | 0.41 |
| ▸ | LCK | P06239 | 2/20 | 0.36 |
| ▸ | KDR | P35968 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 2/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | HCK | P08631 | 1/20 | 0.35 |
| ▸ | KIT | P10721 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.35 |
| ▸ | TEK | Q02763 | 1/20 | 0.35 |
| ▸ | DGAT1 | O75907 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4570063 | 1.00 | CRBN (0.41) | CRBNLCKKDRMAPTCYP1A2 | |
| SCHEMBL17082122 | 0.92 | CRBN (0.43) | CRBNLCKKDRRETABL1 | |
| SCHEMBL4570141 | 0.92 | CRBN (0.43) | CRBNLCKKDRRETABL1 | |
| SCHEMBL4570060 | 0.91 | CRBN (0.42) | CRBNMAPTCYP1A2CYP2C19DGAT1 | |
| SCHEMBL17082012 | 0.91 | CRBN (0.42) | CRBNMAPTCYP1A2CYP2C19DGAT1 | |
| SCHEMBL17082010 | 0.90 | SMN1; SMN2 (0.43) | CRBNMAPTCYP1A2CYP2C19DGAT1 | |
| SCHEMBL4570061 | 0.90 | SMN1; SMN2 (0.43) | CRBNMAPTCYP1A2CYP2C19DGAT1 | |
| SCHEMBL4570062 | 0.90 | CRBN (0.42) | CRBNMAPTCYP1A2CYP2C19DGAT1 | |
| SCHEMBL17082019 | 0.90 | CRBN (0.42) | CRBNMAPTCYP1A2CYP2C19DGAT1 | |
| SCHEMBL4570059 | 0.89 | CRBN (0.44) | CRBNMAPTCYP1A2CYP2C19DGAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1812005-B1 | LACTAM COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORP (US) | 2015-09-16 | — | — | EP | disclosed |