Sugi Predict

Sugi Predict / Compounds / SCHEMBL4570063

SCHEMBL4570063

SCHEMBL4570063

CC(C)COC(=O)Nc1ccc(N2CCC[C@]3(CCN(C4CCOCC4)C3=O)C2)nc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CRBN Q96SW2 2/20 0.41
▸ LCK P06239 2/20 0.36
▸ KDR P35968 2/20 0.36
▸ MAPT P10636 3/20 0.36
▸ CYP1A2 P05177 2/20 0.36
▸ CYP2C19 P33261 1/20 0.36
▸ RET P07949 2/20 0.35
▸ ABL1 P00519 1/20 0.35
▸ HCK P08631 1/20 0.35
▸ KIT P10721 1/20 0.35
▸ SRC P12931 1/20 0.35
▸ PDGFRA P16234 1/20 0.35
▸ TEK Q02763 1/20 0.35
▸ DGAT1 O75907 3/20 0.35
▸ SMN1; SMN2 Q16637 3/20 0.35
▸ LMNA P02545 2/20 0.35
▸ HTT P42858 1/20 0.35
▸ MTOR P42345 1/20 0.34
▸ RAB9A P51151 3/20 0.34
▸ NPC1 O15118 2/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17082006 1.00 CRBN (0.41) CRBNLCKKDRMAPTCYP1A2
SCHEMBL17082122 0.92 CRBN (0.43) CRBNLCKKDRRETABL1
SCHEMBL4570141 0.92 CRBN (0.43) CRBNLCKKDRRETABL1
SCHEMBL4570060 0.91 CRBN (0.42) CRBNMAPTCYP1A2CYP2C19DGAT1
SCHEMBL17082012 0.91 CRBN (0.42) CRBNMAPTCYP1A2CYP2C19DGAT1
SCHEMBL17082010 0.90 SMN1; SMN2 (0.43) CRBNMAPTCYP1A2CYP2C19DGAT1
SCHEMBL4570061 0.90 SMN1; SMN2 (0.43) CRBNMAPTCYP1A2CYP2C19DGAT1
SCHEMBL4570062 0.90 CRBN (0.42) CRBNMAPTCYP1A2CYP2C19DGAT1
SCHEMBL17082019 0.90 CRBN (0.42) CRBNMAPTCYP1A2CYP2C19DGAT1
SCHEMBL4570059 0.89 CRBN (0.44) CRBNMAPTCYP1A2CYP2C19DGAT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20120122858-A1 LACTAM COMPOUNDS AND THEIR USE AS PHARMACEUTICALS INCYTE CORPORATION (US) 2012-05-17 — — US disclosed
US-20120122858-A1 LACTAM COMPOUNDS AND THEIR USE AS PHARMACEUTICALS INCYTE CORPORATION (US) 2012-05-17 — — US disclosed
US-8110581-B2 Lactam compounds and their use as pharmaceuticals INCYTE CORPORATION (US) 2012-02-07 — — US disclosed
US-8110581-B2 Lactam compounds and their use as pharmaceuticals INCYTE CORPORATION (US) 2012-02-07 — — US disclosed
US-20090291946-A1 LACTAM COMPOUNDS AND THEIR USE AS PHARMACEUTICALS INCYTE CORPORATION (US) 2009-11-26 — — US disclosed
US-20090291946-A1 LACTAM COMPOUNDS AND THEIR USE AS PHARMACEUTICALS INCYTE CORPORATION (US) 2009-11-26 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090291946-A1 LACTAM COMPOUNDS AND THEIR USE AS PHARMACEUTICALS HSD11B1, HSD11B2, HSD17B1 CRBN 2898/4885LCK 4619/4885KDR 4054/4885
US-20120122858-A1 LACTAM COMPOUNDS AND THEIR USE AS PHARMACEUTICALS HSD11B1, HSD11B2, HSD17B1 CRBN 2898/4885LCK 4619/4885KDR 4054/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.