Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | DGAT1 | O75907 | 6/20 | 0.37 |
| ▸ | STAT3 | P40763 | 1/20 | 0.37 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.36 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.36 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4570062 | 1.00 | CRBN (0.42) | CRBNMAPTCYP1A2CYP2C19SMN1; SMN2 | |
| SCHEMBL17082086 | 0.92 | CRBN (0.45) | CRBNRAB9ADGAT1KCNQ3KCNQ2 | |
| SCHEMBL4570145 | 0.92 | CRBN (0.45) | CRBNRAB9ADGAT1KCNQ3KCNQ2 | |
| SCHEMBL4570059 | 0.92 | CRBN (0.44) | CRBNMAPTCYP1A2CYP2C19SMN1; SMN2 | |
| SCHEMBL17082068 | 0.92 | CRBN (0.44) | CRBNMAPTCYP1A2CYP2C19SMN1; SMN2 | |
| SCHEMBL4570063 | 0.90 | CRBN (0.41) | CRBNMAPTCYP1A2CYP2C19SMN1; SMN2 | |
| SCHEMBL17082006 | 0.90 | CRBN (0.41) | CRBNMAPTCYP1A2CYP2C19SMN1; SMN2 | |
| SCHEMBL4570060 | 0.89 | CRBN (0.42) | CRBNMAPTCYP1A2CYP2C19SMN1; SMN2 | |
| SCHEMBL17082012 | 0.89 | CRBN (0.42) | CRBNMAPTCYP1A2CYP2C19SMN1; SMN2 | |
| SCHEMBL17082132 | 0.88 | MAPT (0.38) | MAPTCYP1A2CYP2C19SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1812005-B1 | LACTAM COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORP (US) | 2015-09-16 | — | — | EP | disclosed |