Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 2/20 | 0.45 |
| ▸ | DGAT1 | O75907 | 10/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.38 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.36 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.36 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4570143 | 1.00 | CRBN (0.45) | CRBNDGAT1ALDH1A1DDB1PDE7A | |
| SCHEMBL4570144 | 0.93 | CRBN (0.44) | CRBNDGAT1ALDH1A1DDB1PDE7A | |
| SCHEMBL17082171 | 0.93 | CRBN (0.44) | CRBNDGAT1ALDH1A1DDB1PDE7A | |
| SCHEMBL10112720 | 0.92 | DGAT1 (0.43) | CRBNDGAT1ALDH1A1PDE7ATRPV1 | |
| SCHEMBL17082012 | 0.92 | CRBN (0.42) | CRBNDGAT1ALDH1A1PDE7AMAPT | |
| SCHEMBL4570060 | 0.92 | CRBN (0.42) | CRBNDGAT1ALDH1A1PDE7AMAPT | |
| SCHEMBL4570142 | 0.91 | CRBN (0.48) | CRBNALDH1A1DDB1PDE7ATRPV1 | |
| SCHEMBL17082114 | 0.91 | CRBN (0.48) | CRBNALDH1A1DDB1PDE7ATRPV1 | |
| SCHEMBL17082122 | 0.91 | CRBN (0.43) | CRBNDGAT1DDB1PDE7ATRPV1 | |
| SCHEMBL4570141 | 0.91 | CRBN (0.43) | CRBNDGAT1DDB1PDE7ATRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1812005-B1 | LACTAM COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORP (US) | 2015-09-16 | — | — | EP | disclosed |