Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 10/20 | 0.41 |
| ▸ | USP2 | O75604 | 8/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 8/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 6/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | DOCK5 | Q9H7D0 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | BPTF | Q12830 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL549214 | 1.00 | CYP3A4 (0.41) | CYP3A4USP2CYP1A2CYP2C19CYP2C9 | |
| SCHEMBL4570125 | 1.00 | CYP3A4 (0.41) | CYP3A4USP2CYP1A2CYP2C19CYP2C9 | |
| SCHEMBL17082155 | 1.00 | CYP3A4 (0.41) | CYP3A4USP2CYP1A2CYP2C19CYP2C9 | |
| SCHEMBL550490 | 1.00 | CYP3A4 (0.41) | CYP3A4USP2CYP1A2CYP2C19CYP2C9 | |
| SCHEMBL2702321 | 1.00 | CYP3A4 (0.41) | CYP3A4USP2CYP1A2CYP2C19CYP2C9 | |
| SCHEMBL549215 | 1.00 | CYP3A4 (0.41) | CYP3A4USP2CYP1A2CYP2C19CYP2C9 | |
| SCHEMBL4570126 | 1.00 | CYP3A4 (0.41) | CYP3A4USP2CYP1A2CYP2C19CYP2C9 | |
| SCHEMBL550528 | 0.91 | DOCK5 (0.40) | CYP3A4USP2CYP1A2CYP2C19CYP2C9 | |
| SCHEMBL549770 | 0.89 | HSD11B1 (0.38) | HSD11B1 | |
| SCHEMBL550413 | 0.89 | HSD11B1 (0.38) | HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1812005-B1 | LACTAM COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORP (US) | 2015-09-16 | — | — | EP | disclosed |