DOCK5 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL21475552	1.00	9/20
SCHEMBL21481076	1.00	9/20
SCHEMBL21480987	0.92	9/20
SCHEMBL21456931	1.00	8/20
SCHEMBL21456934	1.00	8/20
SCHEMBL21456945	1.00	8/20
SCHEMBL21456946	1.00	8/20
SCHEMBL21456947	1.00	8/20
SCHEMBL21456949	1.00	8/20
SCHEMBL21456951	1.00	8/20
SCHEMBL21456952	1.00	8/20
SCHEMBL21456953	1.00	8/20
SCHEMBL21456954	1.00	8/20
SCHEMBL21456955	1.00	8/20
SCHEMBL21456956	1.00	8/20
SCHEMBL21456957	1.00	8/20
SCHEMBL21456959	1.00	8/20
SCHEMBL21456937	0.87	8/20
SCHEMBL21456939	0.87	8/20
SCHEMBL21481081	0.87	8/20

Clinical trials — most relevant to DOCK5 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Double-blind, Randomized, Placebo-controlled Trial of Ganaxolone in CDKL5 Deficiency Patients 6 Months to Less Than 2 Years Old	PHASE3	NOT_YET_RECRUITING
Cornelia De Lange Syndrome: Assessing Positive Effects of Lithium Treatment	PHASE2/PHASE3	RECRUITING
Pilot Study of Reduced-Intensity Hematopoietic Stem Cell Transplant of DOCK8 Deficiency	PHASE2	ACTIVE_NOT_RECRUITING
Mobilization and Collection of Peripheral Blood Stem Cells in Patients With Fanconi Anemia Using G-CSF and AMD3100	PHASE1/PHASE2	COMPLETED
Melpida: Recombinant Adeno-associated Virus (serotype 9) Encoding a Codon Optimized Human AP4M1 Transgene (hAP4M1opt)	PHASE1/PHASE2	RECRUITING
Identification of Genomic Loci Determining Susceptibility to the Development of High Myopia	nan	COMPLETED
Chromosome 5Q Gene Variants and Asthma-Related Traits	nan	COMPLETED
PCD New Gene Discovery	nan	COMPLETED
The BRAVE Study- The Identification of Genetic Variants Associated With Bicuspid Aortic Valve Using a Combination of Case-control and Family-based Approaches.	nan	RECRUITING
Study of the Pathophysiological Mechanisms Involved in Bleeding Events	nan	COMPLETED
Speech and Short-term Memory Functions in Dyslexia: a Combined MEG and EEG Study	nan	UNKNOWN
Family Myopia Study	nan	COMPLETED
Markers and Mechanisms of Macrovascular Disease in IDDM	nan	COMPLETED
Investigating the Genetic Basis of Pseudoexfoliation Syndrome, Angle-closure Glaucoma and Primary Open-angle Glaucoma	nan	RECRUITING
Characterization of New Candidate Genes in Cases of Human Inherited Thrombocytopenia (CATCH)	nan	COMPLETED
Diaphragmatic Hernia Research & Exploration, Advancing Molecular Science	nan	RECRUITING
Identification of Genetic Basis of Atrioventricular Conduction Defects: From Congenital Forms to Degenerative Forms	nan	UNKNOWN
Pathogenesis of Primary Ciliary Dyskinesia (PCD) Lung Disease	nan	RECRUITING
Better Delineation of CDK13 Related Phenotype and Epigenetic Signature.	nan	UNKNOWN
Mapping Disease Pathways for Biliary Atresia	nan	RECRUITING
Genetic Study of Patients With Primary Ciliary Dyskinesia	nan	COMPLETED
Ganaxolone Expanded Access Program Compassionate Use	nan	NO_LONGER_AVAILABLE
Study of the Value of Trio Exome Sequencing in the Etiological Assessment of Specific Non-syndromic Language and Learning Disorders	nan	RECRUITING
Genetics of Primary Ciliary Dyskinesia	nan	COMPLETED
Identification of an Asthma Susceptibility Gene on 3P	nan	COMPLETED
Whole-genome Sequencing Study in Patients With Diminished Ovarian Reserve	nan	UNKNOWN
Identification of Genetic Variants Associated With Unexpected Infant Death Syndrome	nan	RECRUITING
Human Epilepsy Genetics--Neuronal Migration Disorders Study	nan	RECRUITING
Genetic Studies of Strabismus, Congenital Cranial Dysinnervation Disorders (CCDDs), and Their Associated Anomalies	nan	RECRUITING
Genetics of Endocrine Tumours - Familial Isolated Pituitary Adenoma - FIPA	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a DOCK5 binder may also engage these)

Protein	Name	Similarity
DOCK2	Dedicator of cytokinesis protein 2	1.000	landscape →
B2RY04	—	1.000	B2RY04 →
Q8C3J5	—	1.000	Q8C3J5 →
Q8BUR4	—	0.999	Q8BUR4 →
Q14185	—	0.999	Q14185 →
O74925	—	0.992	O74925 →
Q19555	—	0.991	Q19555 →
Q9TXI7	—	0.991	Q9TXI7 →
Q9VRX1	—	0.991	Q9VRX1 →
Q19954	—	0.991	Q19954 →
A8WTE8	—	0.990	A8WTE8 →
Q24314	—	0.990	Q24314 →
O01763	—	0.990	O01763 →
Q09743	—	0.990	Q09743 →
Q8STE5	—	0.989	Q8STE5 →
Q9STV0	—	0.989	Q9STV0 →
Q54F23	—	0.989	Q54F23 →
Q8WUM0	—	0.989	Q8WUM0 →
Q9W3E1	—	0.989	Q9W3E1 →
Q750S2	—	0.988	Q750S2 →
Q9XZ06	—	0.988	Q9XZ06 →
Q9Y3A3	—	0.988	Q9Y3A3 →
Q5XG71	—	0.988	Q5XG71 →
Q9VFB7	—	0.988	Q9VFB7 →
Q09600	—	0.988	Q09600 →
Q54K32	—	0.988	Q54K32 →
Q9VYG1	—	0.988	Q9VYG1 →
Q8LPK4	—	0.988	Q8LPK4 →
Q9U2Y2	—	0.988	Q9U2Y2 →
B4NBB0	—	0.988	B4NBB0 →