Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 7/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.33 |
| ▸ | LCAT | P04180 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL549782 | 1.00 | HSD11B1 (0.40) | HSD11B1NPC1RAB9AALDH1A1TP53 | |
| SCHEMBL2697948 | 1.00 | HSD11B1 (0.40) | HSD11B1NPC1RAB9AALDH1A1TP53 | |
| SCHEMBL4570129 | 1.00 | HSD11B1 (0.40) | HSD11B1NPC1RAB9AALDH1A1TP53 | |
| SCHEMBL17082157 | 1.00 | HSD11B1 (0.40) | HSD11B1NPC1RAB9AALDH1A1TP53 | |
| SCHEMBL549361 | 1.00 | HSD11B1 (0.40) | HSD11B1NPC1RAB9AALDH1A1TP53 | |
| SCHEMBL550804 | 1.00 | HSD11B1 (0.40) | HSD11B1NPC1RAB9AALDH1A1TP53 | |
| SCHEMBL4570130 | 1.00 | HSD11B1 (0.40) | HSD11B1NPC1RAB9AALDH1A1TP53 | |
| SCHEMBL549101 | 0.90 | ALDH1A1 (0.42) | HSD11B1NPC1RAB9AALDH1A1TP53 | |
| SCHEMBL550344 | 0.88 | HSD11B1 (0.40) | HSD11B1NPC1RAB9AALDH1A1TP53 | |
| SCHEMBL550413 | 0.88 | HSD11B1 (0.38) | HSD11B1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1812005-B1 | LACTAM COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORP (US) | 2015-09-16 | — | — | EP | disclosed |