Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS5 | Q9UNA0 | 6/20 | 0.36 |
| ▸ | MMP2 | P08253 | 3/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.36 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.35 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.34 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.34 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.34 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | DPP4 | P27487 | 2/20 | 0.33 |
| ▸ | PER2 | O15055 | 1/20 | 0.33 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.33 |
| ▸ | HTR7 | P34969 | 2/20 | 0.33 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL551000 | 1.00 | ADAMTS5 (0.36) | ADAMTS5MMP2HSD11B1ADAM17GRIA1 | |
| SCHEMBL550105 | 1.00 | ADAMTS5 (0.36) | ADAMTS5MMP2HSD11B1ADAM17GRIA1 | |
| SCHEMBL4570193 | 1.00 | ADAMTS5 (0.36) | ADAMTS5MMP2HSD11B1ADAM17GRIA1 | |
| SCHEMBL17082186 | 1.00 | ADAMTS5 (0.36) | ADAMTS5MMP2HSD11B1ADAM17GRIA1 | |
| SCHEMBL2702614 | 1.00 | ADAMTS5 (0.36) | ADAMTS5MMP2HSD11B1ADAM17GRIA1 | |
| SCHEMBL10201341 | 1.00 | ADAMTS5 (0.36) | ADAMTS5MMP2HSD11B1ADAM17GRIA1 | |
| SCHEMBL550559 | 0.92 | HSD11B1 (0.36) | ADAMTS5HSD11B1GRIA1GRIA2GRIA3 | |
| SCHEMBL550832 | 0.92 | HSD11B1 (0.36) | ADAMTS5HSD11B1GRIA1GRIA2GRIA3 | |
| SCHEMBL2700964 | 0.92 | HSD11B1 (0.36) | ADAMTS5HSD11B1GRIA1GRIA2GRIA3 | |
| SCHEMBL550833 | 0.92 | HSD11B1 (0.36) | ADAMTS5HSD11B1GRIA1GRIA2GRIA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1812005-B1 | LACTAM COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORP (US) | 2015-09-16 | — | — | EP | disclosed |