Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.32 |
| ▸ | FFAR1 | O14842 | 4/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.32 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.32 |
| ▸ | ACACB | O00763 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1708059 | 0.99 | MAPT (0.35) | MAPTLMNASMN1; SMN2NPSR1NTRK1 | |
| SCHEMBL1708078 | 0.90 | MAPT (0.34) | MAPTLMNASMN1; SMN2NPSR1NTRK1 | |
| SCHEMBL1708163 | 0.89 | MAPT (0.34) | MAPTLMNASMN1; SMN2NPSR1NTRK1 | |
| SCHEMBL1708170 | 0.89 | SMN1; SMN2 (0.32) | MAPTLMNASMN1; SMN2NPSR1CD274 | |
| SCHEMBL1707971 | 0.89 | MAPT (0.34) | MAPTLMNASMN1; SMN2NPSR1NTRK1 | |
| SCHEMBL1708269 | 0.89 | MAPT (0.34) | MAPTLMNASMN1; SMN2NPSR1NTRK1 | |
| SCHEMBL1708058 | 0.87 | FFAR1 (0.42) | FFAR1 | |
| SCHEMBL1708364 | 0.87 | FFAR1 (0.36) | NTRK1CD274FFAR1 | |
| SCHEMBL1708675 | 0.82 | ALDH1A1 (0.33) | MAPTALDH1A1MAPK1 | |
| SCHEMBL1708377 | 0.81 | ALDH1A1 (0.33) | MAPTALDH1A1MAPK1ACACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2440541-A1 | NOVEL FUSED CYCLIC COMPOUND AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2012-04-18 | — | — | EP | disclosed |
| WO-2010143733-A1 | NOVEL FUSED CYCLIC COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-12-16 | — | — | WO | disclosed |