SCHEMBL1708415

SCHEMBL1708415

Nc1nc(N)nc(C#Cc2nc(N)nc(N)n2)n1

nearest known ligand 0.36

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
CASP1 P29466 1/20 0.36
CYP1A2 P05177 1/20 0.36
LMNA P02545 1/20 0.33
POLB P06746 1/20 0.32
ADORA3 P0DMS8 1/20 0.32
ADORA2A P29274 1/20 0.32
ADORA2B P29275 1/20 0.32
ADORA1 P30542 1/20 0.32
HTR2B P41595 1/20 0.30
PDE4D Q08499 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL821688 0.82 LMNA (0.33) CASP1LMNA
SCHEMBL175612 0.76 CASP1 (0.50) CASP1CYP1A2LMNAPOLBADORA3
SCHEMBL25853 0.76
SCHEMBL8465809 0.76 CASP1 (0.50) CASP1CYP1A2LMNAPOLBADORA3
SCHEMBL9583239 0.76 CASP1 (0.50) CASP1CYP1A2LMNAPOLBADORA3
SCHEMBL8356506 0.76 CASP1 (0.50) CASP1CYP1A2LMNAPOLBADORA3
SCHEMBL9579151 0.76 CASP1 (0.50) CASP1CYP1A2LMNAPOLBADORA3
SCHEMBL3526724 0.73 SMN1; SMN2 (0.48) CASP1LMNAADORA2AADORA1
SCHEMBL4596648 0.71 CASP1 (0.47) CASP1CYP1A2LMNAPOLBADORA3
SCHEMBL2477170 0.71 CASP1 (0.47) CASP1CYP1A2LMNAPOLBADORA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10731027-B2 Coupled glass-fiber reinforced polyoxymethylene CELANESE SALES GERMANY GMBH (DE) 2020-08-04 US disclosed
EP-2652001-B1 COUPLED GLASS-FIBER REINFORCED POLYOXYMETHYLENE CELANESE SALES GERMANY GMBH (DE) 2018-12-26 EP disclosed
US-9540553-B2 Weather resistant polyoxymethylene compositions TICONA GMBH (DE) 2017-01-10 US disclosed
US-20160257805-A1 Coupled Glass-Fiber Reinforced Polyoxymethylene TICONA GMBH (DE) 2016-09-08 US disclosed
US-9303145-B2 Coupled glass-fiber reinforced polyoxymethylene TICONA GMBH (DE) 2016-04-05 US disclosed
US-20150299544-A1 Weather Resistant Polyoxymethylene Compositions TICONA GMBH (DE) 2015-10-22 US disclosed
EP-2581408-B1 Tribologically modified glass-fiber reinforced polyoxymethylene TICONA GMBH (DE) 2015-07-29 EP disclosed
US-9062183-B2 Fiber reinforced polyoxymethylene composition with improved thermal properties TICONA GMBH (DE) 2015-06-23 US disclosed
US-20150065654-A1 Tribologically Modified Polyoxymethylene NUTRINOVA NUTRITION SPECIALTIES & FOOD INGREDIENTS GMBH (DE) 2015-03-05 US disclosed
EP-2653497-B1 Weather resistant polyoxymethylene compositions TICONA GMBH (DE) 2015-01-28 EP disclosed
EP-2652001-A1 COUPLED GLASS-FIBER REINFORCED POLYOXYMETHYLENE Ticona GmbH (DE) 2013-10-23 EP disclosed
WO-2013149812-A1 TRIBOLOGICALLY MODIFIED POLYOXYMETHYLENE TICONA GMBH (DE) 2013-10-10 WO disclosed
EP-2647666-A1 Tribologically modified polyoxymethylene Ticona GmbH (DE) 2013-10-09 EP disclosed
EP-2441786-B1 Glass-fiber reinforced polyoxymethylene TICONA GMBH (DE) 2013-07-31 EP disclosed
US-20130102718-A1 Tribologically Modified Glass-Fiber Reinforced Polyoxymethylene TICONA GMBH (DE) 2013-04-25 US disclosed
WO-2013053914-A1 TRIBOLOGICALLY MODIFIED GLASS-FIBER REINFORCED POLYOXYMETHYLENE TICONA GMBH (DE) 2013-04-18 WO disclosed
EP-2581408-A1 Tribologically modified glass-fiber reinforced polyoxymethylene Ticona GmbH (DE) 2013-04-17 EP disclosed
US-20120157588-A1 Glass Fiber-Reinforced Polyoxymethylene TICONA GMBH (DE) 2012-06-21 US disclosed
WO-2012049293-A1 COUPLED GLASS-FIBER REINFORCED POLYOXYMETHYLENE TICONA GMBH (DE) 2012-04-19 WO disclosed
EP-2441786-A1 Glass-fiber reinforced polyoxymethylene Ticona GmbH (DE) 2012-04-18 EP disclosed